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Chen, Jianwei, Jia, Yangyang, Sun, Ying, Liu, Kun, Zhou, Changhao, Liu, Chuan, Li, Denghui, Liu, Guilin, Zhang, Chengsong, Yang, Tao, Huang, Lei, Zhuang, Yunyun, Wang, Dazhi, Xu, Dayou, Zhong, Qiaoling, Guo, Yang, Li, Anduo, Seim, Inge, Jiang, Ling, Wang, Lushan, Lee, Simon Ming Yuen, Liu, Yujing, Wang, Dantong, Zhang, Guoqiang, Liu, Shanshan, Wei, Xiaofeng, Yue, Zhen, Zheng, Shanmin, Shen, Xuechun, Wang, Sen, Qi, Chen, Chen, Jing, Ye, Chen, Zhao, Fang, Wang, Jun, Fan, Jie, Li, Baitao, Sun, Jiahui, Jia, Xiaodong, Xia, Zhangyong, Zhang, He, Liu, Junnian, Zheng, Yue, Liu, Xin, Wang, Jian, Yang, Huanming, Kristiansen, Karsten, Xu, Xun, Mock, Thomas 
ORCID: https://orcid.org/0000-0001-9604-0362, Li, Shengying, Zhang, Wenwei and Fan, Guangyi
(2024)
Global marine microbial diversity and its potential in bioprospecting.
Nature, 633 (8029).
pp. 371-379.
ISSN 0028-0836
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Abstract
The past two decades has witnessed a remarkable increase in the number of microbial genomes retrieved from marine systems1,2. However, it has remained challenging to translate this marine genomic diversity into biotechnological and biomedical applications3,4. Here we recovered 43,191 bacterial and archaeal genomes from publicly available marine metagenomes, encompassing a wide range of diversity with 138 distinct phyla, redefining the upper limit of marine bacterial genome size and revealing complex trade-offs between the occurrence of CRISPR–Cas systems and antibiotic resistance genes. In silico bioprospecting of these marine genomes led to the discovery of a novel CRISPR–Cas9 system, ten antimicrobial peptides, and three enzymes that degrade polyethylene terephthalate. In vitro experiments confirmed their effectiveness and efficacy. This work provides evidence that global-scale sequencing initiatives advance our understanding of how microbial diversity has evolved in the oceans and is maintained, and demonstrates how such initiatives can be sustainably exploited to advance biotechnology and biomedicine.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: This work was supported by the grants of National Key Research and Development Program of China (grant no. 2019YFA0706900), Key Program of Marine Economy Development (Six Marine Industries) Special Foundation of Department of Natural Resources of Guangdong Province (grant no. GDNRC [2023]49), Joint Funds of the National Natural Science Foundation of China (grant no. U2106228), National Natural Science Foundation of China (grant nos. 32100047, 32025001 and 32370124), Major Scientific and Technological Innovation Projects of Qingdao West Coast New Area (grant no. ZDKC-2022-03), Thousands Marine Species Genome Sequencing Project of Qingdao Free Trade Zone Management Committee, Hainan Yazhou Bay Seed Lab (grant no. B23YQ2003), Project of Sanya Yazhou Bay Science and Technology City (grant no. SKJC-2024-02-003), and the State Key Laboratory of Microbial Technology Open Projects Fund (M2023-10). Computations in this study were supported by the High-performance Computing Platform of YZBSTCACC. The authors thank C. Wu for providing bacterial strains for AMP antibacterial tests and the members of the GOMP Consortium for the fruitful discussions for the manuscript preparation. This work is part of the Global Ocean Microbiome Project (GOMP). |
| Uncontrolled Keywords: | sdg 14 - life below water ,/dk/atira/pure/sustainabledevelopmentgoals/life_below_water |
| Faculty \ School: | Faculty of Science > School of Environmental Sciences University of East Anglia Research Groups/Centres > Theme - ClimateUEA |
| UEA Research Groups: | Faculty of Science > Research Centres > Centre for Ecology, Evolution and Conservation Faculty of Science > Research Groups > Centre for Ocean and Atmospheric Sciences Faculty of Science > Research Groups > Environmental Biology |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 04 Dec 2024 01:42 |
| Last Modified: | 09 Dec 2024 01:39 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/97893 |
| DOI: | 10.1038/s41586-024-07891-2 |
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