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ToolsYuan, Jin-Min, Nugent, Christopher, Wilson, Allegra, Verlander, Neville Q., Alexander, Eliza, Fleming, Paul, Modi, Neena, Oughham, Kayleigh, Ratnaraja, Natasha, Wan, Yu, Thorn, Louise, Felgate, Heather, Webber, Mark A., Ogundipe, Enitan, Brown, Colin S., Paranthaman, Karthik and Demirjian, Alicia (2024) Clinical outcomes of Staphylococcus capitis isolation from neonates, England, 2015–2021: A retrospective case–control study. Archives of Disease in Childhood: Fetal and Neonatal Edition, 109 (2). pp. 128-134. ISSN 1359-2998
Full text not available from this repository. (Request a copy)Abstract
Objective: Staphylococcus capitis, a coagulase-negative staphylococci (CoNS) species, has been increasingly detected from UK sterile site samples and has caused neonatal unit outbreaks worldwide. We compared survival to discharge and 30-day mortality for the detection of S. capitis versus other CoNS species. Methods: In this retrospective case–control study, we included hospitalised infants with any CoNS species detected from a normally sterile body site up to 90 days of age. We linked English laboratory reports from the Second Generation Surveillance System database, mortality data from the Personal Demographics Service, and neonatal unit admissions from the National Neonatal Research Database. In primary analysis, multivariable logistic regression was used, with two co-primary outcomes: survival to discharge and death within 30 days of positive specimen date. Sensitivity analyses using multiply imputed datasets followed. Results: We identified 16636 CoNS episodes relating to 13745 infants. CoNS episodes were highest among infants born extremely preterm (22–27 weeks) and with extremely low birth weight (400–999g). In primary analysis, there were no differences in survival to discharge (p=0.71) or 30-day mortality (p=0.77) between CoNS species. In sensitivity analyses, there were no differences in outcomes between infection with four of the most common CoNS species (Staphylococcus epidermidis, S. capitis, Staphylococcus haemolyticus and Staphylococcus warneri) but the remaining CoNS species were at higher risk of adverse outcomes when treated in aggregate. Conclusion: Infants with S. capitis detected from sterile site samples did not experience significant differences in either survival to discharge or 30-day mortality compared with infants with detection of other common CoNS species.
| Item Type: | Article |
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| Additional Information: | Funding Information: YW is an Imperial Institutional Strategic Support Fund Springboard Research Fellow, funded by the Wellcome Trust and Imperial College London. YW, AD and CSB are affiliated with the National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance at Imperial College London in partnership with the UK Health Security Agency (formerly Public Health England), in collaboration with Imperial Healthcare Partners, University of Cambridge and University of Warwick. Publisher Copyright: © Author(s) (or their employer(s)) 2024. |
| Uncontrolled Keywords: | pediatrics, perinatology, and child health,obstetrics and gynaecology ,/dk/atira/pure/subjectarea/asjc/2700/2735 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 03 Dec 2024 01:35 |
| Last Modified: | 03 Dec 2024 01:35 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/97862 |
| DOI: | 10.1136/archdischild-2023-325887 |
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