Tools
ToolsDarby, Elizabeth M., Trampari, Eleftheria, Siasat, Pauline, Gaya, Maria Solsona, Alav, Ilyas, Webber, Mark A. and Blair, Jessica M.A. (2023) Molecular mechanisms of antibiotic resistance revisited. Nature Reviews Microbiology, 21 (5). pp. 280-295. ISSN 1740-1526
Full text not available from this repository. (Request a copy)Abstract
Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics currently in clinical use and only a few novel drugs in the pipeline. Understanding the molecular mechanisms that bacteria use to resist the action of antimicrobials is critical to recognize global patterns of resistance and to improve the use of current drugs, as well as for the design of new drugs less susceptible to resistance development and novel strategies to combat resistance. In this Review, we explore recent advances in understanding how resistance genes contribute to the biology of the host, new structural details of relevant molecular events underpinning resistance, the identification of new resistance gene families and the interactions between different resistance mechanisms. Finally, we discuss how we can use this information to develop the next generation of antimicrobial therapies.
| Item Type: | Article |
|---|---|
| Additional Information: | Publisher Copyright: © 2022, Springer Nature Limited. |
| Uncontrolled Keywords: | microbiology,immunology and microbiology(all),infectious diseases,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2400/2404 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 03 Dec 2024 01:35 |
| Last Modified: | 03 Dec 2024 01:35 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/97856 |
| DOI: | 10.1038/s41579-022-00820-y |
Actions (login required)
 |
View Item |