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Goddard, Zoë R., Searcey, Mark 
ORCID: https://orcid.org/0000-0003-2273-8949 and Osbourn, Anne
(2024)
Advances in triterpene drug discovery.
Trends in Pharmacological Sciences, 45 (11).
pp. 964-968.
ISSN 0165-6147
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Abstract
Triterpenes are structurally complex natural products with promising therapeutic properties. Recalcitrance to chemical synthesis has hindered their use in drug development. Recent advances now make it possible to access and harness triterpene structural diversity using engineering biology approaches, enabling the discovery and optimisation of a new generation of drug leads.
| Item Type: | Article |
|---|---|
| Additional Information: | Acknowledgments: We acknowledge funding from Biotechnology and Biological Sciences Research Council (BBSRC) Follow-on-Fund grant APP4941, Wellcome Discovery Award 227375/Z/23/Z, the BBRSC Institute Strategic Programme Grant ‘Harnessing biosynthesis for sustainable food and health’ (BB/X01097X/1), and the John Innes Foundation. |
| Uncontrolled Keywords: | triterpene,drug discovery,review,plant natural products,drug discovery,triterpenes,metabolic engineering,toxicology,pharmacology ,/dk/atira/pure/subjectarea/asjc/3000/3005 |
| Faculty \ School: | Faculty of Science > School of Chemistry, Pharmacy and Pharmacology |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 07 Nov 2024 10:30 |
| Last Modified: | 13 Nov 2024 10:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/97557 |
| DOI: | 10.1016/j.tips.2024.10.003 |
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