Tools
Tools
Corballis, Natasha, Bhalraam, U., Merinopoulos, Ioannis, Gunawardena, Tharusha, Tsampasian, Vasiliki, Wickramarachchi, Upul, Eccleshall, Simon and Vassiliou, Vassilios S. 
ORCID: https://orcid.org/0000-0002-4005-7752
(2024)
One-month duration compared with twelve-month duration of dual antiplatelet therapy in elective angioplasty for coronary artery disease: Bleeding and ischaemic outcomes.
Journal of Clinical Medicine, 13 (15).
ISSN 2077-0383
Preview |
PDF (jcm-13-04521)
- Published Version
Available under License Creative Commons Attribution. Download (985kB) | Preview |
Abstract
Background/Objectives: The need to determine the safest duration of dual antiplatelet therapy duration after elective angioplasty to reduce bleeding events without an adverse effect on major adverse cardiovascular events (MACE) remains a challenge. Methods: In this investigator-initiated, single-centre cohort study, we identified all patients who underwent PCI for de novo coronary disease for stable angina between January 2015 and November 2019. We compared 1-month and 12-month durations of dual antiplatelet therapy (DAPT) to determine if there was any difference in the primary outcome of major bleeding. The secondary outcome was a patient-oriented composite endpoint of all-cause mortality; any myocardial infarction, stroke, or revascularisation; and the individual components of this composite endpoint. Data were analysed using Cox regression models and cumulative hazard plots. Results: A total of 1025 patients were analysed, of which 340 received 1 month of DAPT and 685 received 12 months of DAPT. There was no difference in major bleeding between the two groups (2.6% vs. 2.5% respectively). On univariable cox regression analysis, no characteristics were predictors of major bleeding. A proportion of 99.7% of patients in the 1-month DAPT arm were treated with a DCB strategy, whilst 93% in the 12-month DAPT group were treated with a DES. There was no difference between the two groups with regards to the composite patient-oriented MACE (11% vs. 12%, respectively) or any individual component of this. These results were unchanged after propensity score matched analysis. Conclusions: A 1-month duration of DAPT, for which 99.7% of patients were treated with a DCB strategy, appears safe and effective when compared with a 12-month duration of DAPT with no difference in major bleeding or MACE.
| Item Type: | Article |
|---|---|
| Additional Information: | Data Availability Statement: The original contributions presented in the study are included in the article/Supplementary Materials, further inquiries can be directed to the corresponding author/s. Funding Information: Corballis and Tsampasian are NIHR DRF students. Eccleshall has received research grants for investigator-initiated research and lecture honoraria from B. Braun and acts as a consultant for B. Braun, Medtronic, and MedAlliance. Vassiliou has received speaker honoraria for Novartis and received a research grant from B. Braun for investigator-initiated research. Merinopoulos receives a research grant from Cordis. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. |
| Uncontrolled Keywords: | bleeding risk,dcb only pci,dual antiplatelet therapy,elective pci,medicine(all) ,/dk/atira/pure/subjectarea/asjc/2700 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 06 Nov 2024 15:30 |
| Last Modified: | 12 Nov 2024 13:31 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/97542 |
| DOI: | 10.3390/jcm13154521 |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |