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Wilson, Emma, Jennings, Barbara Anne 
ORCID: https://orcid.org/0000-0003-3792-9182, Khondoker, Mizanur ORCID: https://orcid.org/0000-0002-1801-1635, Philpott, Carl M. ORCID: https://orcid.org/0000-0002-1125-3236, Prinsley, Peter and Brewer, Daniel S. ORCID: https://orcid.org/0000-0003-4753-9794
(2024)
Epidemiology of Cholesteatoma in the UK Biobank.
Clinical Otolaryngology.
ISSN 1749-4478
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Abstract
Objectives: To identify factors associated with cholesteatoma in a large UK cohort. Although some risk factors are frequently reported (male sex, history of chronic otitis media), other associations require further evidence (deprivation, smoking). Design and Setting: Briefly, 1140 cholesteatoma cases from UK BioBank were compared to 4551 non-cholesteatoma middle ear disease and 493 832 ear disease-free controls. Adjusted odds ratios were calculated for demographic factors including age, sex, ethnicity, deprivation and smoking status with logistic regressions. Odds ratios for overlapping ICD-10 codes are also calculated. Results: Cholesteatoma was significantly associated with sex (Adjusted odds ratio (AOR) for males = 1.33, 95%CI = [1.179–1.491]), age (AOR = 1.02, 95%CI = [1.011–1.026]) and deprivation (AOR = 1.08, 95%CI = [1.059–1.097]) compared to ear disease-free controls (p < 0.001). Age and deprivation distributions for cholesteatoma and non-cholesteatoma ear disease were similar. Although there was no significant association with smoking status, cholesteatoma was significantly associated with the ICD-10 code mental and behavioural disorders due to tobacco use (OR = 2.34, p < 0.001, 95%CI = [1.942, 2.813]). Cholesteatoma was also strongly associated with a wide range of inflammatory middle ear conditions and chronic sinus inflammation, suggesting an increased susceptibility to inflammation of the upper airways. Conclusion: This study shows a large overlap between cholesteatoma and non-cholesteatoma ear disease in terms of numbers and demographics, with sex being a key factor distinguishing between the two, suggesting that there are both common and distinct associated factors.
| Item Type: | Article |
|---|---|
| Additional Information: | Data Availability Statement: The data that support the findings of this study are available in UK BioBank after registering for access: (https://www.ukbiobank.ac.uk/enable-your-research/register). Publicly available demographic data and statistical results from FinnGen release 9 can be accessed via Risteys (https://r9.risteys.finngen.fi/endpoints/H8_CHOLEASTOMA). Funding: Funding for the studentship associated with this project was provided by the University of East Anglia Faculty of Medicine and Health Sciences. Funding for the greater Genetics of Cholesteatoma project was provided by the Bernice Bibby Research trust. Peer Review history: The peer review history for this article is available at https://www.webofscience.com/api/gateway/wos/peer-review/10.1111/coa.14257. |
| Uncontrolled Keywords: | cholesteatoma,epidemiology,hearing loss,middle ear,otitis media,otorhinolaryngology ,/dk/atira/pure/subjectarea/asjc/2700/2733 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Centres > Population Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Respiratory and Airways Group Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
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| Depositing User: | LivePure Connector |
| Date Deposited: | 04 Nov 2024 14:30 |
| Last Modified: | 18 Dec 2024 01:39 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/97460 |
| DOI: | 10.1111/coa.14257 |
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