Tools
Tools
Albert, Anthony P. 
ORCID: https://orcid.org/0000-0002-3596-9634, Jahan, Kazi S., Greenberg, Harry Z. E. and Shamsaldeen, Yousif A.
(2024)
Role for the PIP2-binding protein myristoylated alanine-rich C-kinase substrate in vascular tissue: A novel therapeutic target for cardiovascular disease.
Journal of Cell Communication and Signaling.
ISSN 1873-9601
Abstract
In vascular smooth muscle cells (VSMCs) and vascular endothelial cells (VECs), phosphatidylinositol 4,5-bisphosphate (PIP2) acts as a substrate for phospholipase C (PLC)- and phosphoinositol 3-kinase (PI3K)-mediated signaling pathways and an unmodified ligand at ion channels and other macromolecules, which are key processes in the regulation of cell physiological and pathological phenotypes. It is envisaged that these distinct roles of PIP2 are achieved by PIP2-binding proteins, which act as PIP2 buffers to produce discrete pools of PIP2 that permits targeted release within the cell. This review discusses evidence for the expression, cell distribution, and role of myristoylated alanine-rich C-kinase substrate (MARCKS), a PIP2-binding protein, in cellular signaling and function of VSMCs. The review indicates the possibilities for MARCKS as a therapeutic target for vascular disease involving dysfunctional cell proliferation and migration, endothelial barrier permeability, and vascular contractility such as atherosclerosis, systemic and pulmonary hypertension, and sepsis.
| Item Type: | Article |
|---|---|
| Additional Information: | Data Availability Statement: The data that support the findings of this study are available from the corresponding author upon reasonable request. Funding Information: This work was supported by the British Heart Foundation grants (FS/15/44/31570 and PG/18/69/33870 to Anthony P. Albert), and by the Biotechnological and Biological Scientific Research Council (BB/J007226/1 and BB/M018350/1 to Anthony P. Albert). |
| Uncontrolled Keywords: | contractility,marcks,migration,permeability,pip,proliferation,vascular endothelial cells,vascular smooth muscle cells,biochemistry,molecular biology,cell biology,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1303 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 01 Nov 2024 16:30 |
| Last Modified: | 19 Nov 2024 17:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/97429 |
| DOI: | 10.1002/ccs3.12052 |
Actions (login required)
 |
View Item |