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ToolsSmokvarska, Marija, Bayle, Vincent, Maneta-Peyret, Lilly, Fouillen, Laetitia, Poitout, Arthur, Dongois, Armelle, Fiche, Jean-Bernard, Gronnier, Julien, Garcia, José, Höfte, Herman, Nolmann, Marcelo, Zipfel, Cyril, Maurel, Christophe, Moreau, Patrick, Jaillais, Yvon and Martiniere, Alexandre (2023) The receptor kinase FERONIA regulates phosphatidylserine localization at the cell surface to modulate ROP signaling. Science Advances, 9 (14). ISSN 2375-2548
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Abstract
Cells maintain a constant dialog between the extracellular matrix and their plasma membrane to fine tune signal transduction processes. We found that the receptor kinase FERONIA (FER), which is a proposed cell wall sensor, modulates phosphatidylserine plasma membrane accumulation and nano-organization, a key regulator of Rho GTPase signaling in Arabidopsis. We demonstrate that FER is required for both Rho-of-Plant 6 (ROP6) nano-partitioning at the membrane and downstream production of reactive oxygen species upon hyperosmotic stimulus. Genetic and pharmacological rescue experiments indicate that phosphatidylserine is required for a subset of, but not all, FER functions. Furthermore, application of FER ligand shows that its signaling controls both phosphatidylserine membrane localization and nanodomains formation, which, in turn, tunes ROP6 signaling. Together, we propose that a cell wall–sensing pathway controls via the regulation of membrane phospholipid content, the nano-organization of the plasma membrane, which is an essential cell acclimation to environmental perturbations.
| Item Type: | Article |
|---|---|
| Additional Information: | Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials. Arabidopsis lines generated in this study are deposited to the Eurasian Arabidopsis Stock Center. Funding Information: J.G. was funded by a Long-Term Fellowships from the European Molecular Biology Organization (EMBO LTF number 438-2018). J.G. is currently funded by the German Research Foundation (DFG) grant CRC 1101-A09. C.Z. received funding from European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program under the Grant Agreement 773153 (project IMMUNO-PEPTALK). H.H. is founded by the French National Agency ANR Homeowall (ANR-20-CE11-0008-01//C6627). Y.J. received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement no. 101001097) and by ERC no. 3363360-APPL under FP/2007-2013; Y.J. and A.M. by the innovative project iRhobot from the division of “Biologie et Amélioration des Plantes” (BAP) of INRAE A.M. is funded by the French National Agency ANR CellOsmo (ANR-19-CE20-0008-01). |
| Uncontrolled Keywords: | general ,/dk/atira/pure/subjectarea/asjc/1000 |
| Faculty \ School: | Faculty of Science > The Sainsbury Laboratory |
| UEA Research Groups: | Faculty of Science > Research Groups > Plant Sciences |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 31 Oct 2024 16:30 |
| Last Modified: | 12 Nov 2024 14:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/97391 |
| DOI: | 10.1126/sciadv.add4791 |
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