Tools
Tools
Lindsay, Richard J., Holder, Philippa J., Talbot, Nicholas J. 
ORCID: https://orcid.org/0000-0001-6434-7757 and Gudelj, Ivana
(2023)
Metabolic efficiency reshapes the seminal relationship between pathogen growth rate and virulence.
Ecology Letters, 26 (6).
pp. 896-907.
ISSN 1461-023X
Preview |
PDF (Ecology Letters - 2023 - Lindsay - Metabolic efficiency reshapes the seminal relationship between pathogen growth rate and)
- Published Version
Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
A cornerstone of classical virulence evolution theories is the assumption that pathogen growth rate is positively correlated with virulence, the amount of damage pathogens inflict on their hosts. Such theories are key for incorporating evolutionary principles into sustainable disease management strategies. Yet, empirical evidence raises doubts over this central assumption underpinning classical theories, thus undermining their generality and predictive power. In this paper, we identify a key component missing from current theories which redefines the growth–virulence relationship in a way that is consistent with data. By modifying the activity of a single metabolic gene, we engineered strains of Magnaporthe oryzae with different nutrient acquisition and growth rates. We conducted in planta infection studies and uncovered an unexpected non-monotonic relationship between growth rate and virulence that is jointly shaped by how growth rate and metabolic efficiency interact. This novel mechanistic framework paves the way for a much-needed new suite of virulence evolution theories.
| Item Type: | Article |
|---|---|
| Additional Information: | Open peer review: The peer review history for this article is available at https://www.webofscience.com/api/gateway/wos/peer-review/10.1111/ele.14218. Data availability statement: All data and code are available at https://doi.org/10.6084/m9.figshare.15052347 Funding Information: IG is funded by a European Research Council Consolidator grant (647292 MathModExp), RJL is funded by a Biotechnology and Biological Sciences Research Council-National Science Foundation/BIO grant (BB/T015985/1) to IG and NJT, PJH is funded by a Leverhulme grant (RPG-2019-238) to IG and NJT. NJT is funded by the Gatsby Charitable Foundation. |
| Uncontrolled Keywords: | growth rate,metabolic efficiency,microbial ecology,plant pathogens,synthetic ecology,trade-offs,virulence,ecology, evolution, behavior and systematics ,/dk/atira/pure/subjectarea/asjc/1100/1105 |
| Faculty \ School: | Faculty of Science > The Sainsbury Laboratory |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 29 Oct 2024 14:30 |
| Last Modified: | 04 Nov 2024 11:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/97332 |
| DOI: | 10.1111/ele.14218 |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |