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Albert, Anthony P. 
ORCID: https://orcid.org/0000-0002-3596-9634
(2011)
Gating mechanisms of canonical transient receptor potential channel proteins:Role of phosphoinositols and diacylglycerol.
In:
Transient Receptor Potential Channels.
Advances in Experimental Medicine and Biology
.
UNSPECIFIED, pp. 391-411.
ISBN 9789400702646
Abstract
Canonical transient receptor potential (TRPC) Ca 2+-permeable channels are members of the mammalian TRP super-family of cation channels, and have the closest homology to the founding members, TRP and TRPL, discovered in Drosophila photoreceptors. The TRPC subfamily is composed of 7 subunits (C1-C7, with TRPC2 a pseudogene in humans), which can all combine with one another to form homomeric and heteromeric structures. This review focuses on mechanisms involved in opening TRPC channels (i.e. gating mechanisms). It initially describes work on the involvement of phosphatidylinositol-4,5-bisphosphate (PIP 2) and diacylglycerol (DAG) in gating TRP and TRPL channels in Drosophila, and then discusses evidence that similar gating mechanisms are involved in opening mammalian TRPC channels. It concludes that there are two common activation pathways of mammalian TRPC channels. Non-TRPC1-containing channels are opened by interactions between DAG, the direct activating ligand, and PIP 2, which acts as a physiological antagonist at TRPC proteins. Competitive interactions between an excitatory effect of DAG and an inhibitory action of PIP 2 can also be modulated by IP 3 acting via an IP 3 receptor-independent mechanism. In contrast TRPC1-containing channels are gating by PIP 2, which requires PKC-dependent phosphorylation of TRPC1 proteins.
| Item Type: | Book Section |
|---|---|
| Additional Information: | Funding Information: Work carried out in the laboratory of the author was funded by The Wellcome Trust and the British Heart Foundation. The author would like to thank Prof WA Large and Dr SN Saleh for many helpful discussions and for reading the manuscript. |
| Uncontrolled Keywords: | ca entry,ca -permeable cation channels,canonical transient receptor potential,diacylglycerol,inositol-1,4,5-trisphoshate,phosphatidylinositol-4,5-bisphosphate,phospholipase c,protein kinase c,receptor-operated channels,store-operated channels,biochemistry, genetics and molecular biology(all) ,/dk/atira/pure/subjectarea/asjc/1300 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 29 Oct 2024 09:31 |
| Last Modified: | 03 Nov 2024 07:31 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/97287 |
| DOI: | 10.1007/978-94-007-0265-3_22 |
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