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Contreras, Mauricio P., Lüdke, Daniel, Pai, Hsuan, Toghani, Amir Ali and Kamoun, Sophien 
ORCID: https://orcid.org/0000-0002-0290-0315
(2023)
NLR receptors in plant immunity: Making sense of the alphabet soup.
EMBO Reports, 24 (10).
ISSN 1469-221X
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Abstract
Plants coordinately use cell-surface and intracellular immune receptors to perceive pathogens and mount an immune response. Intracellular events of pathogen recognition are largely mediated by immune receptors of the nucleotide binding and leucine rich-repeat (NLR) classes. Upon pathogen perception, NLRs trigger a potent broad-spectrum immune reaction, usually accompanied by a form of programmed cell death termed the hypersensitive response. Some plant NLRs act as multifunctional singleton receptors which combine pathogen detection and immune signaling. However, NLRs can also function in higher order pairs and networks of functionally specialized interconnected receptors. In this article, we cover the basic aspects of plant NLR biology with an emphasis on NLR networks. We highlight some of the recent advances in NLR structure, function, and activation and discuss emerging topics such as modulator NLRs, pathogen suppression of NLRs, and NLR bioengineering. Multi-disciplinary approaches are required to disentangle how these NLR immune receptor pairs and networks function and evolve. Answering these questions holds the potential to deepen our understanding of the plant immune system and unlock a new era of disease resistance breeding.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding information: Deutsche Forschungsgemeinschaft (DFG): 464864389; EC | ERC | HORIZON EUROPE European Research Council (ERC): 743165; UKRI | Biotechnology and Biological Sciences Research Council (BBSRC): BB/P012574, BBS/E/J/000PR9795, BBS/E/J/000PR9796, BBS/E/J/000PR9797, BBS/E/J/000PR9798, BB/V002937/1. |
| Uncontrolled Keywords: | bioengineering,immunology,nb-lrr,nbs-lrr,nod,biochemistry,molecular biology,genetics ,/dk/atira/pure/subjectarea/asjc/1300/1303 |
| Faculty \ School: | Faculty of Science > The Sainsbury Laboratory Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Science > Research Groups > Plant Sciences |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 25 Oct 2024 16:30 |
| Last Modified: | 17 Dec 2024 01:41 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/97224 |
| DOI: | 10.15252/embr.202357495 |
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