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Lemaître, Jean François, Moorad, Jacob, Gaillard, Jean Michel, Maklakov, Alexei A. 
ORCID: https://orcid.org/0000-0002-5809-1203 and Nussey, Daniel H.
(2024)
A unified framework for evolutionary genetic and physiological theories of aging.
PLoS Biology, 22 (2).
ISSN 1544-9173
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Abstract
Why and how we age are 2 intertwined questions that have fascinated scientists for many decades. However, attempts to answer these questions remain compartmentalized, preventing a comprehensive understanding of the aging process. We argue that the current lack of knowledge about the evolution of aging mechanisms is due to a lack of clarity regarding evolutionary theories of aging that explicitly involve physiological processes: the disposable soma theory (DST) and the developmental theory of aging (DTA). In this Essay, we propose a new hierarchical model linking genes to vital rates, enabling us to critically reevaluate the DST and DTA in terms of their relationship to evolutionary genetic theories of aging (mutation accumulation (MA) and antagonistic pleiotropy (AP)). We also demonstrate how these 2 theories can be incorporated in a unified hierarchical framework. The new framework will help to generate testable hypotheses of how the hallmarks of aging are shaped by natural selection.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: J.-F. L. was supported by a grant from the Agence Nationale de la Recherche (EVORA - ANR-22-CE02-0021). J.-M.G. was supported by a grant from the Agence Nationale de la Recherche (DivInt - ANR-22- CE02-0020). A.A.M. was supported by a grant from ERC CoG (GermlineAgeingSoma 724909) and NERC (NE/ W001020/1). J.A.M. was supported by nobody. D. H.N. and J.-F.L. were supported by a Royal Society International Exchange Grant (IEC\R2\181087). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Authorship was ordered by random draw. |
| Uncontrolled Keywords: | neuroscience(all),biochemistry, genetics and molecular biology(all),immunology and microbiology(all),agricultural and biological sciences(all) ,/dk/atira/pure/subjectarea/asjc/2800 |
| Faculty \ School: | Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Science > Research Centres > Centre for Ecology, Evolution and Conservation Faculty of Science > Research Groups > Organisms and the Environment |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 25 Oct 2024 09:30 |
| Last Modified: | 29 Oct 2024 00:53 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/97198 |
| DOI: | 10.1371/journal.pbio.3002513 |
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