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ToolsJones, Jonathan D. G., Staskawicz, Brian J. and Dangl, Jeffery L. (2024) The plant immune system: From discovery to deployment. Cell, 187 (9). pp. 2095-2116. ISSN 0092-8674
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Abstract
Plant diseases cause famines, drive human migration, and present challenges to agricultural sustainability as pathogen ranges shift under climate change. Plant breeders discovered Mendelian genetic loci conferring disease resistance to specific pathogen isolates over 100 years ago. Subsequent breeding for disease resistance underpins modern agriculture and, along with the emergence and focus on model plants for genetics and genomics research, has provided rich resources for molecular biological exploration over the last 50 years. These studies led to the identification of extracellular and intracellular receptors that convert recognition of extracellular microbe-encoded molecular patterns or intracellular pathogen-delivered virulence effectors into defense activation. These receptor systems, and downstream responses, define plant immune systems that have evolved since the migration of plants to land ∼500 million years ago. Our current understanding of plant immune systems provides the platform for development of rational resistance enhancement to control the many diseases that continue to plague crop production.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: J.D.G.J. gratefully acknowledges funding from the Gatsby Charitable Foundation, BBSRC, The Royal Society and European Research Council. B.J.S. acknowledges funding from the Foundation for Food and Agriculture, 2 Blades Foundation, and the Founders Fund from the Innovative Genomics Institute. J.L.D. acknowledges funding from the National Science Foundation and the Howard Hughes Medical Institute. The authors declare no competing interests. |
| Uncontrolled Keywords: | effector proteins,eti,immune system evolution,pathogen recognition,plant immunology,plant inflammasome,pti,receptor systems,resistosomes,virulence factors,biochemistry, genetics and molecular biology(all),sdg 3 - good health and well-being,sdg 13 - climate action ,/dk/atira/pure/subjectarea/asjc/1300 |
| Faculty \ School: | Faculty of Science > School of Biological Sciences Faculty of Science > The Sainsbury Laboratory |
| UEA Research Groups: | Faculty of Science > Research Groups > Plant Sciences |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 24 Oct 2024 09:30 |
| Last Modified: | 01 Nov 2024 12:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/97173 |
| DOI: | 10.1016/j.cell.2024.03.045 |
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