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Klemm, Elizabeth J., Nisar, Muhammad Imran, Bawn, Matt, Nasrin, Dilruba, Qamar, Farah Naz, Page, Andrew, Qadri, Farheen, Shakoor, Sadia, Zaidi, Anita K. M., Levine, Myron M., Dougan, Gordon and Kingsley, Robert A. 
ORCID: https://orcid.org/0000-0002-0194-6485
(2024)
Genomic analysis of clinical Aeromonas isolates reveals genetic diversity but little evidence of genetic determinants for diarrhoeal disease.
Microbial Genomics, 10 (3).
ISSN 2057-5858
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Abstract
Aeromonas spp. are associated with a number of infectious syndromes in humans including gastroenteritis and dysentery. Our understanding of the genetic diversity, population structure, virulence determinants and antimicrobial resistance of the genus has been limited by a lack of sequenced genomes linked to metadata. We performed a comprehensive analysis of the whole genome sequences of 447 Aeromonas isolates from children in Karachi, Pakistan, with moderate-to-severe diarrhoea (MSD) and from matched controls without diarrhoea that were collected as part of the Global Enteric Multicenter Study (GEMS). Human-associated Aeromonas isolates exhibited high species diversity and extensive antimicrobial and virulence gene content. Aeromonas caviae, A. dhankensis, A. veronii and A. enteropelogenes were all significantly associated with MSD in at least one cohort group. The maf2 and lafT genes that encode components of polar and lateral flagella, respectively, exhibited a weak association with isolates originating from cases of gastroenteritis.
| Item Type: | Article |
|---|---|
| Additional Information: | Data Summary: The authors confirm all supporting data, code and protocols have been provided within the article or through supplementary data files. Sequence data are available in the European Nucleotide Archive (http://www.ebi.ac.uk/ena) under project accession numbers PRJEB15489 and PRJEB1611. Funding Information: R.K. was supported by BBSRC Institute Strategic Programme Microbes in the Food Chain BB/R012504/1 and its constituent projects BBS/E/ F/000PR10348 and BBS/E/F/000PR10349, and Microbes and Food Safety BB/X011011/1 and its constituent projects BBS/E/F/000PR13635 and BBS/E/F/000PR13636. |
| Uncontrolled Keywords: | aeromonas,amr,diarrhoea,gems,genomics,pakistan,virulence,epidemiology,microbiology,molecular biology,genetics,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2713 |
| Faculty \ School: | Faculty of Science > School of Biological Sciences |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 23 Oct 2024 11:30 |
| Last Modified: | 12 Nov 2024 14:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/97148 |
| DOI: | 10.1099/mgen.0.001211 |
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