Septin-dependent invasive growth by the rice blast fungus Magnaporthe oryzae

Eisermann, Iris and Talbot, Nicholas J. ORCID: https://orcid.org/0000-0001-6434-7757 (2024) Septin-dependent invasive growth by the rice blast fungus Magnaporthe oryzae. Journal of Plant Diseases and Protection, 131 (4). pp. 1145-1151. ISSN 1861-3829

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Abstract

Septin GTPases are morphogenetic proteins that are widely conserved in eukaryotic organisms fulfilling diverse roles in cell division, differentiation and development. In the filamentous fungal pathogen Magnaporthe oryzae, the causal agent of the devastating blast diseases of rice and wheat, septins have been shown to be essential for plant infection. The blast fungus elaborates a specialised infection structure called an appressorium with which it mechanically ruptures the plant cuticle. Septin aggregation and generation of a hetero-oligomeric ring structure at the base of the infection cell is indispensable for plant infection. Furthermore, once the fungus enters host tissue it develops another infection structure, the transpressorium, enabling it to move between living host plant cells, which also requires septins for its function. Specific inhibition of septin aggregation—either genetically or with chemical inhibitors—prevents plant infection. Significantly, by screening for inhibitors of septin aggregation, broad spectrum anti-fungal compounds have been identified that prevent rice blast and a number of other cereal diseases in field trials. We review the recent advances in our understanding of septin biology and their potential as targets for crop disease control.

Item Type:	Article
Additional Information:	Acknowledgements: We thank Dr. Marisela Gardu\u00F1o-Rosales from The Sainsbury Laboratory, as well as the JIC Bioimaging facility and staff, especially Dr. Eva Wegel, for the microscopy contribution to this publication. Funding information: European Research Council.
Uncontrolled Keywords:	appressorium,fungi,fungicide,invasive growth,plant pathogens,septins,agronomy and crop science,plant science,horticulture ,/dk/atira/pure/subjectarea/asjc/1100/1102
Faculty \ School:	Faculty of Science > The Sainsbury Laboratory
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	23 Oct 2024 11:30
Last Modified:	17 Dec 2024 01:41
URI:	https://ueaeprints.uea.ac.uk/id/eprint/97139
DOI:	10.1007/s41348-024-00883-4

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