Immunology of Fungal Infections

Middleton, Georgie and Bidula, Stefan (2025) Immunology of Fungal Infections. In: Encyclopedia of Immunobiology. Elsevier, V4:6-V4:17. ISBN 9780123742797

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Abstract

There are an immeasurable number of fungal species. Fortunately, only a handful cause harm to humans and the immune system is very adept at dealing with the fungal threat. However, in the immune compromised, such as those with underlying infections like COVID-19 or undergoing whole organ or stem cell transplants, fungal infections can be life-threatening. This issue has been further exacerbated by the emergence of antifungal drug resistance. Consequently, it is critical that we understand how fungal infections are recognized and cleared by the immune system to aid in the development of adjunctive immunotherapies. Here, we highlight the nonredundant role of innate immunity in controlling fungal infection with a particular focus on phagocytes and pattern recognition receptors, before describing the adaptive immune response comprising of dendritic cells, B and T cells. Finally, we overview the important advances in the development of immunotherapeutic strategies being employed for antifungal defense.

Item Type:	Book Section
Uncontrolled Keywords:	adaptive immunity,b cells,fungi,immunotherapy,infection,innate immunity,pamps,pattern recognition receptors,phagocytes,t cells,medicine(all),immunology and microbiology(all) ,/dk/atira/pure/subjectarea/asjc/2700
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Pathogen Biology Group Faculty of Science > Research Groups > Pharmacology and Biological Chemistry
Related URLs:	http://www.scopus.com/inward/record.url?... https://linkinghub.elsevier.com/retrieve...
Depositing User:	LivePure Connector
Date Deposited:	19 Oct 2024 00:09
Last Modified:	13 Feb 2026 01:03
URI:	https://ueaeprints.uea.ac.uk/id/eprint/97072
DOI:	10.1016/B978-0-128-24465-4.00027-2

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