Purinergic P2X Receptors as Therapeutic Targets

Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781, Bidula, Stefan ORCID: https://orcid.org/0000-0002-3790-7138 and Sluyter, Ronald (2024) Purinergic P2X Receptors as Therapeutic Targets. In: Ion Channels as Targets in Drug Discovery. Springer, pp. 439-460. ISBN 9783031521966

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Abstract

Purinergic P2X receptors are ATP-gated ion channels involved in cation flux across membranes. P2X receptors are assembled as trimers from three identical subunits (homomeric) or from a combination of subunits (heteromeric) and display different biophysical and pharmacological properties. This chapter provides an overview of the P2X family and their roles in various disease states as documented over the last 20 years. We highlight the potential of multiple P2X receptors as therapeutic targets for inflammatory disorders, psychiatric disorders, pain disorders, chronic cough and cancer.

Item Type:	Book Section
Additional Information:	Publisher Copyright: © The Author(s), Springer Nature Switzerland AG 2024.
Uncontrolled Keywords:	cancer,chronic cough,inflammatory disorders,p2x,pain disorders,psychiatric disorders,purinergic receptors,medicine(all),pharmacology, toxicology and pharmaceutics(all),neuroscience(all) ,/dk/atira/pure/subjectarea/asjc/2700
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	18 Oct 2024 10:30
Last Modified:	18 Oct 2024 10:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/97070
DOI:	10.1007/978-3-031-52197-3_13

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