Practicality, validity and responsiveness of using the proxy version of the CHU-9D with children aged 2 to 5 years

Sach, Tracey H. ORCID: https://orcid.org/0000-0002-8098-9220, Williams, Hywel C., Allen, Hilary, Boyle, Robert, Kelleher, Maeve, Brown, Sara, Cork, Mike, Flohr, Carsten, Jay, Nicola, Lartey, Stella ORCID: https://orcid.org/0000-0001-9519-7886, Davies, Charlotte, Lawton, Sandra, Perkin, Michael, Ridd, Matthew, Sach, Tracey H. ORCID: https://orcid.org/0000-0002-8098-9220, Brooks, Joanne, Haines, Rachel, Mitchell, Eleanor, Montgomery, Alan, Swinden, Richard, Tarr, Stella, Wyatt, Laura, Thomas, Kim, Williams, Hywel, Chalmers, Joanne and Davies-Jones, Susan and BEEP Study Team (2024) Practicality, validity and responsiveness of using the proxy version of the CHU-9D with children aged 2 to 5 years. Value in Health. ISSN 1098-3015

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Abstract

Objectives: To assess the practicality, validity and responsiveness of proxy CHU-9D in children aged 2-5 years. Methods: We used data from BEEP, a UK randomised controlled trial testing whether daily emollients in infancy could prevent eczema in high-risk infants. The main parent/carer completed the proxy CHU-9D using developers’ additional guidance for completion in under-5’s and the Patient-Orientated Eczema Measure (POEM) at ages 2, 3, 4 and 5. Practicality was assessed by completion rates. Construct validity assessed if CHU-9D could discriminate between those with/without eczema and between eczema severity levels on POEM. Responsiveness was determined by ability to discriminate between three groups: those whose POEM score, i) deteriorated ≥3 points, ii) change not clinically important (-2.9 to 2.9 points), and iii) improved ≥3 points. Analysis was conducted in STATA 17. Results: Of 1,394 children participating in BEEP, study questionnaires were completed by 1,212 (87%), 981 (70%), 990 (71%), and 976 (70%) at 2, 3, 4 and 5-years. Of these the CHU-9D was completed by 1,066 (88.0%), 685 (69.8%), 925 (93.4%) and 923 (94.6%) respectively. Mean utility at all timepoints was around 0.934 (range 0.443-1). For construct validity, very small differences on the CHU-9D between known groups were observed (p Conclusions: Proxy CHU-9D in 2-5 year old children shows potential but further research is needed.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Science > School of Environmental Sciences Faculty of Science
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Health Economics Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre
Depositing User:	LivePure Connector
Date Deposited:	15 Oct 2024 16:30
Last Modified:	16 Oct 2024 14:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/97032
DOI:	10.1016/j.jval.2024.08.010

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