Causes of musculoskeletal pain in Paget’s disease of bone

Berg, Kathryn, Dockrell, Dervil, Colvin, Lesley, Fraser, William D., Tang, Jonathan C. Y. ORCID: https://orcid.org/0000-0001-6305-6333, Aspray, Terry, Dennison, Elaine, Divyateja, Hrushikesh, Ghouri, Nazim, Hanison, Esther, Keen, Richard, McCloskey, Eugene, O'Neill, Terence W., Rahman, Faizanur, Siddiqi, Mashood, Tuck, Stephen, Turton, Jane and Ralston, Stuart H. (2024) Causes of musculoskeletal pain in Paget’s disease of bone. Calcified Tissue International. ISSN 0171-967X

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Abstract

Paget’s disease of bone (PDB) is characterised by increased and disorganised bone remodelling leading to various complications, such as bone deformity, deafness, secondary osteoarthritis, and pathological fracture. Pain is the most common presenting symptom of PDB, but it is unclear to what extent this is due to increased metabolic activity of the disease, complications, or unrelated causes. We conducted a cross-sectional study of 168 people with PDB attending secondary care referral centres in the UK. We documented the presence of musculoskeletal pain and sought to determine its underlying causes. Musculoskeletal pain was reported by 122/168 (72.6%) individuals. The most common cause was osteoarthritis of joints distant from an affected PDB site in 54 (44.3%), followed by metabolically active PDB in 18 (14.7%); bone deformity in 14 (11.4%); osteoarthritis of a joint neighbouring an affected site in 11 (9.0%), neuropathic pain in 10 (8.2%), and various other causes in the remainder. Pain was more common in women (p

Item Type:	Article
Additional Information:	Funding information: This research was supported in part by a grant to Stuart H Ralston, Lesley Colvin, and William D Fraser by the Paget’s Association (UK) and by a research bursary to Kathryn Berg from the Paget’s Association (UK). The research leading to these results has received funding from the European Research Council under the European Union’s Horizon 2020 Framework Programme (787270-Paget-Advance). Open access funding was provided by the University of Edinburgh.
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	LivePure Connector
Date Deposited:	07 Oct 2024 16:30
Last Modified:	13 Oct 2024 06:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96933
DOI:	10.1007/s00223-024-01279-0

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