Spatial growth rate of emerging SARS-CoV-2 lineages in England, September 2020-December 2021

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Smallman-Raynor, M. R. and Cliff, A. D. and The COVID-19 Genomics UK (COG-UK) Consortium (2022) Spatial growth rate of emerging SARS-CoV-2 lineages in England, September 2020-December 2021. Epidemiology and Infection, 150. ISSN 0950-2688

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Abstract

This paper uses a robust method of spatial epidemiological analysis to assess the spatial growth rate of multiple lineages of SARS-CoV-2 in the local authority areas of England, September 2020-December 2021. Using the genomic surveillance records of the COVID-19 Genomics UK (COG-UK) Consortium, the analysis identifies a substantial (7.6-fold) difference in the average rate of spatial growth of 37 sample lineages, from the slowest (Delta AY.4.3) to the fastest (Omicron BA.1). Spatial growth of the Omicron (B.1.1.529 and BA) variant was found to be 2.81× faster than the Delta (B.1.617.2 and AY) variant and 3.76× faster than the Alpha (B.1.1.7 and Q) variant. In addition to AY.4.2 (a designated variant under investigation, VUI-21OCT-01), three Delta sublineages (AY.43, AY.98 and AY.120) were found to display a statistically faster rate of spatial growth than the parent lineage and would seem to merit further investigation. We suggest that the monitoring of spatial growth rates is a potentially valuable adjunct to outbreak response procedures for emerging SARS-CoV-2 variants in a defined population.

Item Type: Article
Additional Information: Data availability statement: The data that support the findings of this study are available at Wellcome Sanger Institute COVID–19 Genomic Surveillance (https://covid19.sanger.ac.uk/lineages/raw).
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Science
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Depositing User: LivePure Connector
Date Deposited: 26 Sep 2024 15:30
Last Modified: 02 Oct 2024 09:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/96817
DOI: 10.1017/S0950268822001285

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