Pregnancy vitamin D supplementation and offspring bone mineral density in childhood Follow-up of a randomised controlled trial

Moon, Rebecca J., Angelo, Stefania D’, Curtis, Elizabeth M., Ward, Kate A., Crozier, Sarah R., Schoenmakers, Inez, Javaid, M. Kassim, Bishop, Nicholas J., Godfrey, Keith M., Cooper, Cyrus, Harvey, Nicholas C., Dennison, Elaine M., Eastell, Richard, Fraser, Robert, Gandhi, Saurabh V., Inskip, Hazel M., Kennedy, Stephen H., Papageorghiou, Aris T. and Prentice, Ann and the MAVIDOS Trial Group (2024) Pregnancy vitamin D supplementation and offspring bone mineral density in childhood Follow-up of a randomised controlled trial. The American Journal of Clinical Nutrition. ISSN 0002-9165

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Abstract

Background Findings from the MAVIDOS trial demonstrated a positive effect of gestational cholecalciferol supplementation on offspring bone mineral density (BMD) at age 4 years. Demonstrating persistence of this effect is important to understanding whether maternal vitamin D supplementation could be a useful public health strategy to improving bone health. Objective We investigated whether gestational vitamin D supplementation increases offspring BMD at 6-7 years in an exploratory post-hoc analysis of an existing trial. Methods In the MAVIDOS randomised controlled trial, pregnant females Results 454 children were followed up at age 6-7 years, of whom 447 had a usable DXA scan. Gestational cholecalciferol supplementation resulted in higher WBLH BMC (0.15 SD, 95%CI 0.04, 0.26), BMD (0.18 SD, 95%CI 0.06,0.31), BMAD (0.18 SD, 95%CI 0.04,0.32) and lean mass (0.09 SD, 95%CI 0.00,0.17) compared to placebo. The effect of pregnancy cholecalciferol on bone outcomes was similar at ages 4 and 6-7 years. Conclusions and relevance Supplementation with cholecalciferol 1000 IU/day during pregnancy resulted in greater offspring BMD and lean mass in mid-childhood versus placebo in this exploratory post-hoc analysis. These findings suggest that pregnancy vitamin D supplementation may be an important population health strategy to improve bone health.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Depositing User:	LivePure Connector
Date Deposited:	24 Sep 2024 12:56
Last Modified:	24 Sep 2024 12:56
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96803
DOI:	10.1016/j.ajcnut.2024.09.014

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