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Perri, Giorgia, Mathers, John C., Martin-Ruiz, Carmen, Parker, Craig, Demircan, Kamil, Chillon, Thilo S., Schomburg, Lutz, Robinson, Louise, Stevenson, Emma J., Shannon, Oliver M., Muniz-Terrera, Graciela, Sniehotta, Falko F., Ritchie, Craig W., Adamson, Ashley, Burns, Alistair, Minihane, Anne-Marie 
ORCID: https://orcid.org/0000-0001-9042-4226, Walsh, Jennifer and Hill, Tom R.
(2024)
The association between selenium status and global and attention specific cognition in very old adults in The Newcastle 85+ Study: Cross-sectional and longitudinal analyses.
American Journal of Clinical Nutrition.
ISSN 0002-9165
Abstract
Background: Selenium has potential safeguarding properties against cognitive decline, because of its role in protecting DNA, proteins, and lipids in the brain from oxidative damage. However, acute and chronic overexposure to selenium can be neurotoxic. Objective: The aim of this analysis was to explore the association between selenium status [serum selenium and selenoprotein P (SELENOP) concentrations and glutathione peroxidase 3 (GPx3) activity] and cognitive function in 85-y olds living in Northeast England at baseline and ≤5 y of follow-up. Methods: Global cognitive performance was assessed in 755 participants from the Newcastle 85+ study using the standardized Mini-Mental State Examination and attention-specific cognition was assessed using composite scores derived from the Cognitive Drug Research System. Serum selenium, SELENOP, and GPx3 activity were measured at baseline by total reflection X-ray fluorescence, enzyme-linked immunosorbent assay, and coupled-enzyme reaction, respectively. Regression analyses explored linear and nonlinear associations between continuous values and tertiles of selenium status biomarkers, respectively, and cognitive function at baseline. Generalized linear mixed models explored associations between continuous values and tertiles of selenium status biomarkers, and global cognitive decline over 5 y, and attention-specific cognitive decline over 3 y. Results: Over 3 and 5 y, none of the selenium biomarkers were associated with the rate of cognitive decline. At baseline, in fully adjusted models, higher serum selenium was nonlinearly associated with global cognition (β = 0.05 ± 0.01, P = 0.387 linear, β = 0.04 ± 0.01, P = 0.002 nonlinear). SELENOP and GPx3 activity were not associated with any cognitive outcomes. Conclusions: There were no associations between selenium status and cognitive decline. However, serum selenium, but not SELENOP or GPx3 activity, was positively associated nonlinearly with global cognition at baseline. Furthermore, these associations were not evident during follow-up, potentially because of residual confounding and reverse causation.
| Item Type: | Article |
|---|---|
| Additional Information: | Data Availability Statement: Data described in the manuscript is available upon request. Funding information: The Newcastle 85+ Study was jointly funded by the Medical Research Council and Biotechnology and Biomedical Science Research Council (G0500997), now part of UK Research and Innovation (UKRI) in addition to the Newcastle Healthcare Charity. The following waves were funded by the Dunhill Medical Trust (R124/0509), Newcastle University, UK Medical Research Council and the British Heart Foundation (606013333). Overall, the project was supported by National Institute for Health Research Newcastle Biomedical Research Centre based at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University. Analyses in the lab of LS were supported by Deutsche Forschungsgemeinschaft (DFG Research Unit 2558 TraceAge, Scho 849/6–2 and CRC/TR 296 ‘Local control of TH action’, LocoTact, P17). This work was part supported by the Medical Research Council (MRC) and Versus Arthritis as part of the Medical Research Council Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing (CIMA) [MR/R502182/1]. The MRC Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing is a collaboration between the Universities of Liverpool, Sheffield and Newcastle. We would also like to acknowledge the generous donations provided by Cumbria Community Foundation and Beverley Charitable Trust Fund throughout the associated PhD programme of study. The NuBrain consortium is funded by a UK Nutrition Research Partnership (UK NRP) Collaborative Award, an initiative supported by the Medical Research Council (MRC), Biotechnology and Biological Sciences Research Council (BBSRC) and the National Institute for Health Research (NIHR). The project reference is MR/T001852/1. |
| Uncontrolled Keywords: | nubrain,cognition,selenium status,selenoprotein p,very old adults,medicine (miscellaneous),nutrition and dietetics ,/dk/atira/pure/subjectarea/asjc/2700/2701 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 13 Sep 2024 16:30 |
| Last Modified: | 17 Oct 2024 09:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96754 |
| DOI: | 10.1016/j.ajcnut.2024.09.004 |
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