Studies on the exchange of valine-oxygen during the biosynthesis of δ-(L-α-Aminoadipoyl)-L-cysteinyl-D-valine

Tools

Baldwin, Jack E., Adlington, Robert M., Bird, Juliette W., Field, Robert A. ORCID: https://orcid.org/0000-0001-8574-0275, O'Callaghan, Niamh M. and Schofield, Christopher J. (1992) Studies on the exchange of valine-oxygen during the biosynthesis of δ-(L-α-Aminoadipoyl)-L-cysteinyl-D-valine. Tetrahedron, 48 (6). pp. 1099-1108. ISSN 0040-4020

Full text not available from this repository. (Request a copy)

Abstract

Incorporation of [4-2H6,18O2]-valine into δ-(L)-α-aminoadipoyl)-L-cysteinyl-D-valine (ACV), by intact cells of Cephalosporium acremonium, demonstrated the intracellular exchange of one and both valine oxygen atoms. Incubation of [18O2]-valine with the purified ACV synthetase from C. acremonium gave exclusive incorporation of a single 18O label into ACV, consistent witheffectively non-reversible formation of a covalent valinoyl-ACV synthetase intermediate under in vitro conditions.

Item Type:	Article
Uncontrolled Keywords:	biosynthesis,cephalosporium acremonium,penicillin.,[o]-valine incorporation,δ-(l-α-aminoadipoyl)-l-cysteinyl-d-valine (acv),biochemistry,drug discovery,organic chemistry ,/dk/atira/pure/subjectarea/asjc/1300/1303
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	11 Sep 2024 14:30
Last Modified:	25 Sep 2024 18:09
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96725
DOI:	10.1016/S0040-4020(01)88205-3

Actions (login required)

View Item