Proline 4-hydroxylase: Stereochemical course of the reaction

Baldwin, Jack E., Field, Robert A. ORCID: https://orcid.org/0000-0001-8574-0275, Lawrence, Christopher C., Merritt, Kirsten D. and Schofield, Christopher J. (1993) Proline 4-hydroxylase: Stereochemical course of the reaction. Tetrahedron Letters, 34 (46). pp. 7489-7492. ISSN 0040-4039

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Abstract

The stereochemical course of the hydroxylation of (S)-proline by proline 4-hydroxylase from Streptomyces griseoviridus P8648 has been investigated using (2S, 4S)-[4-2H1]-proline and (2S, 4R)-[4-2H1]-proline and found to occur with retention of stereochemistry at C-4 of proline.

Item Type:	Article
Uncontrolled Keywords:	biochemistry,drug discovery,organic chemistry ,/dk/atira/pure/subjectarea/asjc/1300/1303
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
Related URLs:	https://www.scopus.com/pages/publication...
Depositing User:	LivePure Connector
Date Deposited:	11 Sep 2024 14:30
Last Modified:	18 Jun 2026 20:21
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96723
DOI:	10.1016/S0040-4039(00)60161-2

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