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Probert, Mark A., Milton, Mark J., Harris, Richard, Schenkman, Sergio, Brown, Jonathan M., Romans, Steven W. and Field, Robert A. 
ORCID: https://orcid.org/0000-0001-8574-0275
(1997)
Chemoenzymatic synthesis of GM3, Lewis x and sialyl Lewis x oligosaccharides in 13C-enriched form.
Tetrahedron Letters, 38 (33).
pp. 5861-5864.
ISSN 0040-4039
Abstract
In connection with studies on the solution and protein-bound conformation of oligosaccharides, wand had reason to consider the application of 13C-enriched sugars. Herein we describe the synthesis of ganglioside GM3 trisaccharide (1), Lewis x trisaccharide (2) and the sialyl Lewis x tetrasaccharide (3) from [U-13C]-D-Glc, [U-13C]- and [U-13C]-pyruvate.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: We acknowledge support from the Wellcome Trust (Grants 040331/Z/93/Z to SWH, and 042472/Z/94/Z to RAF) and the Zeneca Strategic Research Fund (RAF). Jennifer Harrison and Shona Smith are thanked for assistance with enzyme production. Dr Ravi Kartha is thanked for helpful advice. We are grateful to Monica Palcic and Cathy Compston (University of Alberta) for supplying milk fucosyltransferase and for much helpful advice. Angela Mehlert and Mike Ferguson (University of Dundee) are thanked for providing ES-MS data. |
| Uncontrolled Keywords: | biochemistry,drug discovery,organic chemistry ,/dk/atira/pure/subjectarea/asjc/1300/1303 |
| Faculty \ School: | Faculty of Science > School of Chemistry, Pharmacy and Pharmacology |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 11 Sep 2024 09:30 |
| Last Modified: | 25 Sep 2024 18:09 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96708 |
| DOI: | 10.1016/S0040-4039(97)01304-X |
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