An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators

Butler, Anthony R., Field, Robert A. ORCID: https://orcid.org/0000-0001-8574-0275, Greig, Iain R., Flitney, Frederick W., Bisland, Stuart K., Khan, Faisel and Belch, Jill J. F. (1997) An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators. Nitric Oxide - Biology and Chemistry, 1 (3). pp. 211-217. ISSN 1089-8603

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Abstract

A number of S-nitrosated compounds derived from 1-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized. Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally.

Item Type:	Article
Uncontrolled Keywords:	biochemistry,physiology,clinical biochemistry,cancer research,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1303
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	11 Sep 2024 09:30
Last Modified:	25 Sep 2024 18:09
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96705
DOI:	10.1006/niox.1997.0125

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