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Brown, Jillian R., Smith, Terry K., Ferguson, Michael A. J. and Field, Robert A. 
ORCID: https://orcid.org/0000-0001-8574-0275
(1998)
A synthetic acceptor substrate for Trypanosoma brucei UDP-Gal: GPI anchor side-chain α-galactosyltransferases.
Bioorganic and Medicinal Chemistry Letters, 8 (15).
pp. 2051-2054.
ISSN 0960-894X
Abstract
A synthetic analogue of a trisaccharide fragment of the Trypanosoma brucei Variant Surface Glycoprotein (VSG) GlycosylPhosphatidylInositiol (GPI) anchor, Gal-α-l,3(Man-α-1,6)-Man-α-O-octyl (1), serves as a substrate for two T. brucei α-galactosyltransferases. The principle tetrasaccharide product derived from (1) contains a Gal-α-1,2-Gal linkage.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: We acknowledge support from the Wellcome Trust (Programme Grant to MAJF), the BBSRC (studentship to JRB) and the Zeneca Strategic Research Fund (RAF). MAJF is a Howard Hughes Medical Institute International Research Scholar. Professor J.S. Brimacombe, Dr M.L.S. Gtither, Dr K.P.R. Kartha and Dr T.J. Rutherford are thanked for invaluable advice and assistance. |
| Uncontrolled Keywords: | biochemistry,molecular medicine,molecular biology,pharmaceutical science,drug discovery,clinical biochemistry,organic chemistry ,/dk/atira/pure/subjectarea/asjc/1300/1303 |
| Faculty \ School: | Faculty of Science > School of Chemistry, Pharmacy and Pharmacology |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 11 Sep 2024 09:30 |
| Last Modified: | 25 Sep 2024 18:09 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96697 |
| DOI: | 10.1016/S0960-894X(98)00359-X |
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