The GPI biosynthetic pathway as a therapeutic target for African sleeping sickness

Ferguson, Michael A. J., Brimacombe, John S., Brown, Jillian R., Crossman, Arthur, Dix, Alexander, Field, Robert A. ORCID: https://orcid.org/0000-0001-8574-0275, Güther, M. Lucia S., Milne, Kenneth G., Sharma, Deepak K. and Smith, Terry K. (1999) The GPI biosynthetic pathway as a therapeutic target for African sleeping sickness. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1455 (2-3). pp. 327-340. ISSN 0925-4439

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Abstract

African sleeping sickness is a debilitating and often fatal disease caused by tsetse fly transmitted African trypanosomes. These extracellular protozoan parasites survive in the human bloodstream by virtue of a dense cell surface coat made of variant surface glycoprotein. The parasites have a repertoire of several hundred immunologically distinct variant surface glycoproteins and they evade the host immune response by antigenic variation. All variant surface glycoproteins are anchored to the plasma membrane via glycosylphosphatidylinositol membrane anchors and compounds that inhibit the assembly or transfer of these anchors could have trypanocidal potential. This article compares glycosylphosphatidylinositol biosynthesis in African trypanosomes and mammalian cells and identifies several steps that could be targets for the development of parasite-specific therapeutic agents. Copyright (C) 1999 Elsevier Science B.V.

Item Type:	Article
Additional Information:	Funding Information: The authors’ work is supported by a Programme Grant (054491) from The Wellcome Trust.
Uncontrolled Keywords:	biosynthesis,glycosylphosphatidylinositol,glycosyltransferase,gpi,trypanosome,molecular medicine,molecular biology,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1313
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	11 Sep 2024 09:30
Last Modified:	25 Sep 2024 18:08
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96693
DOI:	10.1016/S0925-4439(99)00058-7

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