Adaptation of an NMR signal suppression pulse sequence for the selective removal of benzylic methylene signals of benzyl ether-protected carbohydrates

Rutherford, Trevor J., Kartha, K. P.Ravindranathan, Readman, S. Kristy, Cura, Peter and Field, Robert A. ORCID: https://orcid.org/0000-0001-8574-0275 (1999) Adaptation of an NMR signal suppression pulse sequence for the selective removal of benzylic methylene signals of benzyl ether-protected carbohydrates. Tetrahedron Letters, 40 (10). pp. 2025-2028. ISSN 0040-4039

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Abstract

Application of the DPFGSE-TOCSY pulse sequence permits the selective removal of benzylic signals from the 1H NMR spectra of benzyl ether- protected glycosides. Anomeric proton signals, which have a similar chemical shift, can be readily re-introduced with the aid of a TOCSY sequence. This approach is useful in cases where intense spectral overlap does not permit the straightforward identification of anomeric signals, and hence definition of anomeric configuration or determination of anomeric ratios. The representative application of this pulse sequence to analysis of iodine- promoted thioglycoside activation is reported.

Item Type:	Article
Uncontrolled Keywords:	biochemistry,drug discovery,organic chemistry ,/dk/atira/pure/subjectarea/asjc/1300/1303
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	11 Sep 2024 09:30
Last Modified:	25 Sep 2024 18:08
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96690
DOI:	10.1016/S0040-4039(99)00108-2

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