Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans-sialidase towards NeuAc-α-2,3-Gal-β-O-PNP

Harrison, Jennifer A., Kartha, K. P. Ravindranathan, Turnbull, W. Bruce, Scheuerl, Shona L., Naismith, James H., Schenkman, Sergio and Field, Robert A. (2001) Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans-sialidase towards NeuAc-α-2,3-Gal-β-O-PNP. Bioorganic and Medicinal Chemistry Letters, 11 (2). pp. 141-144. ISSN 0960-894X

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Abstract

NeuAc-α-2,3-Gal-β-O-PNP has been synthesised and its ability to act as a substrate for the hydrolase and transferase activities of Trypanosoma cruzi trans-sialidase have been investigated. The turn-over of this compound shows marked differences from the behaviour of NeuAc-MU. In addition, distinct differences in the action of T. cruzi trans-sialidase and Clostridium perfringens neuraminidase on NeuAc-α-2,3-Gal-β-O-PNP were apparent.

Item Type:	Article
Additional Information:	Funding Information: This work was supported by the BBSRC, the Wellcome Trust (Grant refs: 042472 and 040331), GlaxoWellcome, and the Association for International Cancer Research.
Uncontrolled Keywords:	biochemistry,molecular medicine,molecular biology,pharmaceutical science,drug discovery,clinical biochemistry,organic chemistry ,/dk/atira/pure/subjectarea/asjc/1300/1303
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	10 Sep 2024 12:30
Last Modified:	28 Jan 2025 23:29
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96660
DOI:

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