Synthesis and evaluation of mimetics of UDP and UDP-α-D-galactose, dTDP and dTDP-α-D-glucose with monosaccharides replacing the key pyrophosphate unit

Ballell, Lluis, Young, Robert J. and Field, Robert A. ORCID: https://orcid.org/0000-0001-8574-0275 (2005) Synthesis and evaluation of mimetics of UDP and UDP-α-D-galactose, dTDP and dTDP-α-D-glucose with monosaccharides replacing the key pyrophosphate unit. Organic and Biomolecular Chemistry, 3 (6). pp. 1109-1115. ISSN 1477-0520

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Abstract

A series of 5′-O-glycosyl-uridine and thymidine derivatives have been prepared as potential mimics of sugar nucelotides and nucleotide-diphosphates. These compounds proved not to be inhibitors of bovine β-1,4- galactosyltransferase although some showed moderate inhibition of Salmonella dTDP-a-D-glucose 4,6-dehydratase (RmlB).

Item Type:	Article
Additional Information:	Acknowledgements: These studies were supported by the GlaxoSmithKline Action TB programme and the Weston Foundation. We thank Dr James Errey for assistance with enzyme assays, Professor Jim Naismith (University of St Andrews) for kindly providing the RmlB expression construct and the EPSRC Mass Spectrometry Service Centre, Swansea for invaluable support.
Uncontrolled Keywords:	biochemistry,physical and theoretical chemistry,organic chemistry ,/dk/atira/pure/subjectarea/asjc/1300/1303
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	10 Sep 2024 12:30
Last Modified:	25 Sep 2024 18:08
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96644
DOI:	10.1039/b500418g

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