Synthesis of mucin glycans from the protozoon parasite Trypanosoma cruzi

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Van Well, Renate M., Collet, Beatrice Y.M. and Field, Robert A. ORCID: https://orcid.org/0000-0001-8574-0275 (2008) Synthesis of mucin glycans from the protozoon parasite Trypanosoma cruzi. Synlett (14). pp. 2175-2177. ISSN 0936-5214

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Abstract

A short, blockwise, 2+2-glycosylation approach to the synthesis of a tetrasaccharide component of Trypanosoma cruzi mucin is reported. Despite the use of a 1,2-linked disaccharide donor, high yield (79%) and good stereocontrol (>10:1, β:α) were achieved in the key glycosylation step. Preliminary studies indicate that this branched tetrasaccharide can serve as a substrate for enzymatic sialylation by the parasite cell surface trans-sialidase.

Item Type:	Article
Uncontrolled Keywords:	drug target,mucin,oligosaccharide,parasite,synthesis,trans-sialidase,organic chemistry ,/dk/atira/pure/subjectarea/asjc/1600/1605
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology Faculty of Science > School of Biological Sciences
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	06 Sep 2024 13:35
Last Modified:	25 Sep 2024 18:07
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96604
DOI:	10.1055/s-2008-1078249

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