Synthesis of prospective disaccharide ligands for Escherichia coli O157 verotoxin

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Bernlind, Christian, Homans, Steven W. and Field, Robert A. ORCID: https://orcid.org/0000-0001-8574-0275 (2009) Synthesis of prospective disaccharide ligands for Escherichia coli O157 verotoxin. Tetrahedron Letters, 50 (26). pp. 3397-3399. ISSN 0040-4039

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Abstract

The synthesis of new potential ligands for Escherichia coli 0157 verotoxin is reported, based on disaccharide fragments of the tetrasaccharide glycan portion of Gb4 glycolipid. Intramolecular aglycone delivery was employed for the high-yielding and stereoselective production of the azidopropyl-tethered α-galactoside building block.

Item Type:	Article
Additional Information:	Funding Information: We acknowledge support from the BBSRC and the Knut and Alice Wallenberg Foundation (fellowship to C.B.).
Uncontrolled Keywords:	disaccharide,gb,glycosylation,intramolecular aglycone delivery (iad),verotoxin,biochemistry,drug discovery,organic chemistry ,/dk/atira/pure/subjectarea/asjc/1300/1303
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology Faculty of Science > School of Biological Sciences
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	06 Sep 2024 13:35
Last Modified:	25 Sep 2024 18:07
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96599
DOI:	10.1016/j.tetlet.2009.02.131

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