A simple method of synthesis of triterpene glycosides similar to glycyrrhizic acid and their hepatoprotective activity in vitro

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Mikhailova, L. R., Baltina, L. A., Baltina, L. A., Kondratenko, R. M., Nepogodiev, S. A., Field, R. A. ORCID: https://orcid.org/0000-0001-8574-0275, Kunert, O. and Yin, M. C. (2009) A simple method of synthesis of triterpene glycosides similar to glycyrrhizic acid and their hepatoprotective activity in vitro. Bioorganicheskaia khimiia, 35 (5). pp. 686-695. ISSN 0132-3423

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Abstract

A simplified method of synthesis of triterpene l,2-trans-glycosides was developed using the glycosylation of glycyrrhetic acid (GLA) and 18,19-dehydro-GLA by beta-pyranose peracetates in the presence of SnCl(4) and molecular sieves 4 A. The synthesized glycosides exhibited hepatoprotective activity toward the human hepatoma HepG2 cell line on the model of alcohol hepatitis and decreased the level of TNF-alpha protein.

Item Type: Article
Uncontrolled Keywords: medicine(all),sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700
Faculty \ School: Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
Faculty of Science > School of Biological Sciences
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Depositing User: LivePure Connector
Date Deposited: 06 Sep 2024 13:34
Last Modified: 25 Sep 2024 18:07
URI: https://ueaeprints.uea.ac.uk/id/eprint/96594
DOI:

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