Synthesis of a 'Manno-Gb 3' analogue as a potential shiga toxin/verotoxin inhibitor

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Kartha, K. P. Ravindranathan, Homans, Steven W. and Field, Robert A. ORCID: https://orcid.org/0000-0001-8574-0275 (2010) Synthesis of a 'Manno-Gb 3' analogue as a potential shiga toxin/verotoxin inhibitor. Trends in Carbohydrate Research, 2 (2). pp. 14-19. ISSN 0975-0304

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Abstract

A highly facile stereospecific synthesis of 'manno-Gb3' trisaccharide as its 2-(trimethylsilyl)ethyl glycoside is reported in which the crucial glycosylation reaction of the appropriately protected lactoside acceptor 10 with acetobromomannose was carried out using molecular iodine in excellent yield. The Gb3 analogue 3 is expected to serve as an inhibitor of Shiga/Shiga-like toxins.

Item Type:	Article
Uncontrolled Keywords:	'manno-gb3' synthesis,iodine-promoted glycosylation,verotoxin inhibitor,stereospecific oligosaccharide synthesis,organic chemistry ,/dk/atira/pure/subjectarea/asjc/1600/1605
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology Faculty of Science > School of Biological Sciences
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	06 Sep 2024 13:34
Last Modified:	25 Sep 2024 18:07
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96589
DOI:

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