An expedient enzymatic route to isomeric 2-, 3- and 6-monodeoxy-monofluoro- maltose derivatives

Tantanarat, Krit, Rejzek, Martin, O'Neill, Ellis, Ruzanski, Christian, Hill, Lionel, Fairhurst, Shirley A., Limpaseni, Tipaporn and Field, Robert A. ORCID: https://orcid.org/0000-0001-8574-0275 (2012) An expedient enzymatic route to isomeric 2-, 3- and 6-monodeoxy-monofluoro- maltose derivatives. Carbohydrate Research, 358. pp. 12-18. ISSN 0008-6215

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Abstract

2-Deoxy-2-fluoro-d-glucose, 3-deoxy-3-fluoro-d-glucose and 6-deoxy-6-fluoro-d-glucose were converted into the corresponding maltose derivatives using Arabidopsis thaliana DPE2-mediated trans-glycosylation reaction with glycogen acting as a glucosyl donor. 19F NMR spectroscopy proved to be a valuable tool for monitoring the progress of these reactions and to assess the nature of resulting oligomeric products.

Item Type:	Article
Additional Information:	Funding Information: K.T. was a recipient of the Royal Golden Jubilee PhD Fellowship from the Thailand Research Fund. The authors also received financial supports from the 90th Anniversary of Chulalongkorn University Fund (Ratchadaphiseksomphot Endowment Fund), the Higher Education Research Promotion and National Research University Project of Thailand, Office of the Higher Education Commission (FW650B) and the Thai Government Stimulus Package 2 (TKK 2555) under the Project PERFECTA. Studies conducted at the John Innes Centre were supported by the UK Biotechnology and Biological Sciences Research Council in the form of a Core Strategic grant and studentships to EO’N and CR.
Uncontrolled Keywords:	f nmr spectroscopy,fluoroglucose,fluoromaltose,glycogen,trans-glycosylation,analytical chemistry,biochemistry,organic chemistry ,/dk/atira/pure/subjectarea/asjc/1600/1602
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	04 Sep 2024 13:36
Last Modified:	25 Sep 2024 18:06
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96553
DOI:	10.1016/j.carres.2012.05.026

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