'TamiGold':Phospha-oseltamivir-stabilised gold nanoparticles as the basis for influenza therapeutics and diagnostics targeting the neuraminidase (instead of the hemagglutinin)

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Stanley, Mathew, Cattle, Nicholas, McCauley, John, Martin, Stephen R., Rashid, Abdul, Field, Robert A. ORCID: https://orcid.org/0000-0001-8574-0275, Carbain, Benoit and Streicher, Hansjörg (2012) 'TamiGold':Phospha-oseltamivir-stabilised gold nanoparticles as the basis for influenza therapeutics and diagnostics targeting the neuraminidase (instead of the hemagglutinin). MedChemComm, 3 (11). pp. 1373-1376. ISSN 2040-2503

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Abstract

The strong and selective binding of 2 types of gold nanoparticles that are decorated with the oseltamivir (aka Tamiflu™) pharmacophore to wild-type and resistant influenza virus strains, including isolates from the 2009 pandemic, is reported. The particles interact with the virus neuraminidase rather than the hemagglutinin and could serve as a vantage point for novel influenza virus sensors, due to the intrinsic advantages of oseltamivir over the natural sialic acid ligand or even zanamivir.

Item Type:	Article
Uncontrolled Keywords:	biochemistry,molecular medicine,pharmacology,pharmaceutical science,drug discovery,organic chemistry ,/dk/atira/pure/subjectarea/asjc/1300/1303
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	04 Sep 2024 13:36
Last Modified:	25 Sep 2024 18:06
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96552
DOI:	10.1039/c2md20034a

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