'TamiGold':Phospha-oseltamivir-stabilised gold nanoparticles as the basis for influenza therapeutics and diagnostics targeting the neuraminidase (instead of the hemagglutinin)

Stanley, Mathew, Cattle, Nicholas, McCauley, John, Martin, Stephen R., Rashid, Abdul, Field, Robert A., Carbain, Benoit and Streicher, Hansjörg (2012) 'TamiGold':Phospha-oseltamivir-stabilised gold nanoparticles as the basis for influenza therapeutics and diagnostics targeting the neuraminidase (instead of the hemagglutinin). MedChemComm, 3 (11). pp. 1373-1376. ISSN 2040-2503

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Abstract

The strong and selective binding of 2 types of gold nanoparticles that are decorated with the oseltamivir (aka Tamiflu™) pharmacophore to wild-type and resistant influenza virus strains, including isolates from the 2009 pandemic, is reported. The particles interact with the virus neuraminidase rather than the hemagglutinin and could serve as a vantage point for novel influenza virus sensors, due to the intrinsic advantages of oseltamivir over the natural sialic acid ligand or even zanamivir.

Item Type:	Article
Uncontrolled Keywords:	biochemistry,molecular medicine,pharmacology,pharmaceutical science,drug discovery,organic chemistry ,/dk/atira/pure/subjectarea/asjc/1300/1303
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	04 Sep 2024 13:36
Last Modified:	16 Oct 2025 04:34
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96552
DOI:	10.1039/c2md20034a

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