Structural dissection of the maltodextrin disproportionation cycle of the Arabidopsis plastidial disproportionating enzyme 1 (DPE1)

O'Neill, Ellis C., Stevenson, Clare E.M., Tantanarat, Krit, Latousakis, Dimitrios, Donaldson, Matthew I., Rejzek, Martin, Nepogodiev, Sergey A., Limpaseni, Tipaporn, Field, Robert A. and Lawson, David M. (2015) Structural dissection of the maltodextrin disproportionation cycle of the Arabidopsis plastidial disproportionating enzyme 1 (DPE1). Journal of Biological Chemistry, 290 (50). pp. 29834-29853. ISSN 0021-9258

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Abstract

Background: Arabidopsis maltodextrin disproportionating enzyme 1 (AtDPE1) plays a key role in chloroplast starch degradation. Results: Six AtDPE1 structures define the active site and reveal mechanistically relevant conformations of both the enzyme and substrate. Conclusion: Substrates are captured through loop rearrangements; the subtle deployment of active site residues controls catalysis. Significance: A molecular level understanding of the complete disproportionation cycle of AtDPE1 is presented.

Item Type:	Article
Additional Information:	Publisher Copyright: © 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.
Uncontrolled Keywords:	biochemistry,molecular biology,cell biology ,/dk/atira/pure/subjectarea/asjc/1300/1303
Faculty \ School:	Faculty of Science > School of Biological Sciences Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	04 Sep 2024 13:35
Last Modified:	06 Feb 2025 12:13
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96535
DOI:	10.1074/jbc.M115.682245

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