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O'Neill, Ellis C., Stevenson, Clare E.M., Tantanarat, Krit, Latousakis, Dimitrios, Donaldson, Matthew I., Rejzek, Martin, Nepogodiev, Sergey A., Limpaseni, Tipaporn, Field, Robert A. 
ORCID: https://orcid.org/0000-0001-8574-0275 and Lawson, David M.
(2015)
Structural dissection of the maltodextrin disproportionation cycle of the Arabidopsis plastidial disproportionating enzyme 1 (DPE1).
Journal of Biological Chemistry, 290 (50).
pp. 29834-29853.
ISSN 0021-9258
Abstract
Background: Arabidopsis maltodextrin disproportionating enzyme 1 (AtDPE1) plays a key role in chloroplast starch degradation. Results: Six AtDPE1 structures define the active site and reveal mechanistically relevant conformations of both the enzyme and substrate. Conclusion: Substrates are captured through loop rearrangements; the subtle deployment of active site residues controls catalysis. Significance: A molecular level understanding of the complete disproportionation cycle of AtDPE1 is presented.
| Item Type: | Article |
|---|---|
| Additional Information: | Publisher Copyright: © 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A. |
| Uncontrolled Keywords: | biochemistry,molecular biology,cell biology ,/dk/atira/pure/subjectarea/asjc/1300/1303 |
| Faculty \ School: | Faculty of Science > School of Biological Sciences Faculty of Science > School of Chemistry, Pharmacy and Pharmacology |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 04 Sep 2024 13:35 |
| Last Modified: | 25 Sep 2024 18:06 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96535 |
| DOI: | 10.1074/jbc.M115.682245 |
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