Carbohydrate CuAAC click chemistry for therapy and diagnosis

He, Xiao Peng, Zeng, Ya Li, Zang, Yi, Li, Jia, Field, Robert A. ORCID: https://orcid.org/0000-0001-8574-0275 and Chen, Guo Rong (2016) Carbohydrate CuAAC click chemistry for therapy and diagnosis. Carbohydrate Research, 429. pp. 1-22. ISSN 0008-6215

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Abstract

Carbohydrates are important as signaling molecules and for cellular recognition events, therefore offering scope for the development of carbohydrate-mimetic diagnostics and drug candidates. As a consequence, the construction of carbohydrate-based bioactive compounds and sensors has become an active research area. While the advent of click chemistry has greatly accelerated the progress of medicinal chemistry and chemical biology, recent literature has seen an extensive use of such approaches to construct functionally diverse carbohydrate derivatives. Here we summarize some of the progress, covering the period 2010 to mid-2015, in CuI-catalyzed azide-alkyne 1,3-dipolar cycloaddition CuAAC "click chemistry" of carbohydrate derivatives, in the context of potential therapeutic and diagnostic tool development.

Item Type:	Article
Additional Information:	Funding Information: This research is supported by the 973 project ( 2013CB733700 ), the National Natural Science Foundation of China ( 21572058 and 21576088 ), Key Project of the Shanghai Science and Technology Commission ( 13NM1400900 ), Fundamental Research Funds for Central Universities ( 222201414010 ), the UK BBSRC Institute Strategic Programme Grant on Understanding and Exploiting Metabolism (MET) [ BB/J004561/1 ] and the John Innes Foundation . Publisher Copyright: © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license.
Uncontrolled Keywords:	carbohydrate,click chemistry,cuaac,diagnosis,therapy,analytical chemistry,biochemistry,organic chemistry ,/dk/atira/pure/subjectarea/asjc/1600/1602
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	04 Sep 2024 13:35
Last Modified:	25 Sep 2024 18:06
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96529
DOI:	10.1016/j.carres.2016.03.022

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