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O'Neill, E. C., Saalbach, G. and Field, R. A. 
ORCID: https://orcid.org/0000-0001-8574-0275
(2016)
Gene Discovery for Synthetic Biology:Exploring the Novel Natural Product Biosynthetic Capacity of Eukaryotic Microalgae.
In:
Methods in Enzymology.
Methods in Enzymology
.
Academic Press Inc., pp. 99-120.
Abstract
Eukaryotic microalgae are an incredibly diverse group of organisms whose sole unifying feature is their ability to photosynthesize. They are known for producing a range of potent toxins, which can build up during harmful algal blooms causing damage to ecosystems and fisheries. Genome sequencing is lagging behind in these organisms because of their genetic complexity, but transcriptome sequencing is beginning to make up for this deficit. As more sequence data becomes available, it is apparent that eukaryotic microalgae possess a range of complex natural product biosynthesis capabilities. Some of the genes concerned are responsible for the biosynthesis of known toxins, but there are many more for which we do not know the products. Bioinformatic and analytical techniques have been developed for natural product discovery in bacteria and these approaches can be used to extract information about the products synthesized by algae. Recent analyses suggest that eukaryotic microalgae produce many complex natural products that remain to be discovered.
| Item Type: | Book Section |
|---|---|
| Additional Information: | Funding Information: The authors would like to thank L.H. for assistance with the mass spectrometry and M.R. for general advice on natural product chemistry. The authors gratefully acknowledge support from the BBSRC Institute Strategic Programme Grant on Understanding and Exploiting Metabolism (MET) (BB/J004561/1), the BBSRC Open Plant Synthetic Biology Centre (BB/L014130/1), and the John Innes Foundation. Publisher Copyright: © 2016 Elsevier Inc. |
| Uncontrolled Keywords: | euglena,genome mining,harmful algal blooms,nonribosomal peptide,polyketide,transcriptome,biochemistry,molecular biology ,/dk/atira/pure/subjectarea/asjc/1300/1303 |
| Faculty \ School: | Faculty of Science > School of Chemistry, Pharmacy and Pharmacology |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 04 Sep 2024 13:30 |
| Last Modified: | 24 Sep 2024 08:28 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96521 |
| DOI: | 10.1016/bs.mie.2016.03.005 |
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