Influence of vitamin D supplementation on muscle strength and exercise capacity in South African schoolchildren: Secondary outcomes from a randomised controlled trial (ViDiKids)

Middelkoop, Keren, Micklesfield, Lisa K., Hemmings, Stephanie, Walker, Neil, Stewart, Justine, Jolliffe, David A., Mendham, Amy E., Tang, Jonathan C. Y. ORCID: https://orcid.org/0000-0001-6305-6333, Cooper, Cyrus, Harvey, Nicholas C., Wilkinson, Robert J. and Martineau, Adrian R. (2024) Influence of vitamin D supplementation on muscle strength and exercise capacity in South African schoolchildren: Secondary outcomes from a randomised controlled trial (ViDiKids). BMJ Open Sport and Exercise Medicine. ISSN 2055-7647 (In Press)

Microsoft Word (OpenXML) (ViDiKids_CT_exercise_R1_accepted_23AUG24) - Accepted Version Restricted to Repository staff only until 31 December 2099. Available under License Unspecified licence. Request a copy

Abstract

Objective: To determine whether vitamin D supplementation influences grip strength, explosive leg power, cardiorespiratory fitness and risk of exercise-induced bronchoconstriciton (EIB) in South African schoolchildren.   Methods: Sub-study (n=450) in Cape Town schoolchildren aged 8-11 years, nested within a phase 3 randomised placebo-controlled trial (ViDiKids). The intervention was weekly oral doses of 10,000 IU vitamin D3 (n=228) or placebo (n=222) for 3 years. Outcome measures were serum 25-hydroxyvitamin D3 (25[OH]D3) concentrations, grip strength, standing long jump distance, peak oxygen uptake (VO2peak , determined using 20-metre multi-stage shuttle run tests) and the proportion of children with EIB, measured at end-study.   Results: 64.7% of participants had serum 25(OH)D3 concentrations <75 nmol/L at baseline. At 3-year follow-up, children randomised to vitamin D vs. placebo had higher mean serum 25(OH)D3 concentrations (97.6 vs. 58.8 nmol/L respectively; adjusted mean difference [aMD] 39.9 nmol/L, 95% CI 36.1 to 43.6). However, this was not associated with end-study differences in grip strength, standing long jump distance, VO2peak , or risk of EIB.   Conclusion: A 3-year course of weekly oral supplementation with 10,000 IU vitamin D3 elevated serum 25(OH)D3 concentrations in South African schoolchildren but did not influence muscle strength, exercise capacity or risk of EIB.

Item Type:	Article
Additional Information:	Data availability statement: Anonymised data are available from corresponding authors upon reasonable request, subject to terms of IRB and regulatory approval. Funding information: This research was funded by the UK Medical Research Council (refs MR/R023050/1 and MR/M026639/1, both awarded to ARM). RJW was supported by Wellcome (104803, 203135). He also received support from the Francis Crick Institute which is funded by Cancer Research UK (FC2112), the UK Medical Research Council (FC2112) and Wellcome (FC2112). NCH and CC are supported by the UK Medical Research Council [MC_PC_21003; MC_PC_21001]. RJW is also supported in part by the NIHR Biomedical Research Centre of Imperial College NHS Trust.
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	LivePure Connector
Date Deposited:	04 Sep 2024 10:36
Last Modified:	04 Sep 2024 10:36
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96515
DOI:	issn:2055-7647

Actions (login required)

View Item