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Middelkoop, Keren, Micklesfield, Lisa K., Hemmings, Stephanie, Walker, Neil, Stewart, Justine, Jolliffe, David A., Mendham, Amy E., Tang, Jonathan C. Y. 
ORCID: https://orcid.org/0000-0001-6305-6333, Cooper, Cyrus, Harvey, Nicholas C., Wilkinson, Robert J. and Martineau, Adrian R.
(2024)
Influence of vitamin D supplementation on muscle strength and exercise capacity in South African schoolchildren: Secondary outcomes from a randomised controlled trial (ViDiKids).
BMJ Open Sport and Exercise Medicine, 10 (3).
ISSN 2055-7647
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Abstract
Objective To determine whether vitamin D supplementation influences grip strength, explosive leg power, cardiorespiratory fitness and risk of exercise-induced bronchoconstriction (EIB) in South African schoolchildren. Methods Substudy (n=450) in Cape Town schoolchildren aged 8-11 years nested within a phase 3 randomised placebo-controlled trial (ViDiKids). The intervention was weekly oral doses of 10 000 IU vitamin D 3 (n=228) or placebo (n=222) for 3 years. Outcome measures were serum 25-hydroxyvitamin D 3 (25(OH)D 3) concentrations, grip strength, standing long jump distance, peak oxygen uptake (VO 2peak, determined using 20 m multistage shuttle run tests) and the proportion of children with EIB, measured at end-study. Results 64.7% of participants had serum 25(OH)D 3 concentrations <75 nmol/L at baseline. At 3-year follow-up, children randomised to vitamin D versus placebo had higher mean serum 25(OH)D 3 concentrations (97.6 vs 58.8 nmol/L, respectively; adjusted mean difference 39.9 nmol/L, 95% CI 36.1 to 43.6). However, this was not associated with end-study differences in grip strength, standing long jump distance, VO 2peak or risk of EIB. Conclusion A 3-year course of weekly oral supplementation with 10 000 IU vitamin D 3 elevated serum 25(OH)D 3 concentrations in South African schoolchildren but did not influence muscle strength, exercise capacity or risk of EIB.
| Item Type: | Article |
|---|---|
| Additional Information: | Data availability statement: Anonymised data are available from corresponding authors upon reasonable request, subject to terms of IRB and regulatory approval. Funding information: This research was funded by the UK Medical Research Council (refs MR/R023050/1 and MR/M026639/1, both awarded to ARM). RJW was supported by Wellcome (104803, 203135). He also received support from the Francis Crick Institute which is funded by Cancer Research UK (FC2112), the UK Medical Research Council (FC2112) and Wellcome (FC2112). NCH and CC are supported by the UK Medical Research Council [MC_PC_21003; MC_PC_21001]. RJW is also supported in part by the NIHR Biomedical Research Centre of Imperial College NHS Trust. |
| Uncontrolled Keywords: | children's health and exercise,fitness testing,nutrition,orthopedics and sports medicine,physical therapy, sports therapy and rehabilitation ,/dk/atira/pure/subjectarea/asjc/2700/2732 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 04 Sep 2024 10:36 |
| Last Modified: | 21 Oct 2024 09:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96515 |
| DOI: | 10.1136/bmjsem-2024-002019 |
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