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De-Souza, Evandro A., Thompson, Maximillian A. and Taylor, Rebecca C. 
ORCID: https://orcid.org/0000-0003-3429-3123
(2023)
Olfactory chemosensation extends lifespan through TGF-β signaling and UPR activation.
Nature Aging, 3 (8).
938–947.
ISSN 2662-8465
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Abstract
Animals rely on chemosensory cues to survive in pathogen-rich environments. In Caenorhabditis elegans, pathogenic bacteria trigger aversive behaviors through neuronal perception and activate molecular defenses throughout the animal. This suggests that neurons can coordinate the activation of organism-wide defensive responses upon pathogen perception. In this study, we found that exposure to volatile pathogen-associated compounds induces activation of the endoplasmic reticulum unfolded protein response (UPR ER) in peripheral tissues after xbp-1 splicing in neurons. This odorant-induced UPR ER activation is dependent upon DAF-7/transforming growth factor beta (TGF-β) signaling and leads to extended lifespan and enhanced clearance of toxic proteins. Notably, rescue of the DAF-1 TGF-β receptor in RIM/RIC interneurons is sufficient to significantly recover UPR ER activation upon 1-undecene exposure. Our data suggest that the cell non-autonomous UPR ER rewires organismal proteostasis in response to pathogen detection, pre-empting proteotoxic stress. Thus, chemosensation of particular odors may be a route to manipulation of stress responses and longevity.
| Item Type: | Article |
|---|---|
| Additional Information: | Data availability statement: All data reported in this paper will be shared by the lead contact upon reasonable request. Any additional information required to re-analyze the data reported in this paper is available from the lead contact upon reasonable request. This paper does not report original code. Source data are provided with this paper. Acknowledgements: We are grateful to the Medical Research Council Laboratory of Molecular Biology (MRC-LMB) Visual Aids department for assistance with figures. Some C. elegans strains were provided by A. Dillin (UC Berkeley), W. Schafer (MRC-LMB), J. Tullet (University of Kent), D. Kim (Harvard Medical School) and the Caenorhabditis Genetics Center, which is funded by the National Institutes of Health Office of Research Infrastructure Programs (P40 OD010440). This work was supported by the MRC (R.C.T.) and by the European Union’s Horizon 2020 Research and Innovation Programme under Marie Skłodowska‐Curie grant agreement number 894039 (E.A.D.-S.). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. |
| Uncontrolled Keywords: | neuroscience (miscellaneous),ageing,geriatrics and gerontology ,/dk/atira/pure/subjectarea/asjc/2800/2801 |
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| Depositing User: | LivePure Connector |
| Date Deposited: | 03 Sep 2024 15:35 |
| Last Modified: | 04 Dec 2024 01:41 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96482 |
| DOI: | 10.1101/2022.10.12.511902 |
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