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Kuperman, Ofir Aharon, de Andrade, Peterson, Sui, Xiao Meng, Maria, Raquel, Kaplan-Ashiri, Ifat, Jiang, Qixiang, Terlier, Tanguy, Kirkensgaard, Jacob Judas Kain, Field, Robert A. 
ORCID: https://orcid.org/0000-0001-8574-0275 and Natalio, Filipe
(2024)
Harnessing precursor-directed biosynthesis with glucose derivatives to access cotton fibers with enhanced physical properties.
Cell Reports Physical Science, 5 (5).
ISSN 2666-3864
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Abstract
Cotton ovule in vitro cultures are a promising platform for exploring biofabrication of fibers with tailored properties. When the ovules' growth medium is supplemented with chemically synthesized cellulose precursors, it results in their integration into the developing fibers, thereby tailoring their end properties. Here, we report the feeding of synthetic glucosyl phosphate derivative, 6-deoxy-6-fluoro-glucose-1-phosphate (6F-Glc-1P) to cotton ovules growing in vitro, demonstrating the metabolic incorporation of 6F-Glc into the fibers with enhanced mechanical properties and moisture-retention capacity while emphasizing the role of molecular hierarchical architecture in defining functional characteristics and mechanical properties. This incorporation strategy bypasses the early steps of conventional metabolic pathways while broadening the range of functionalities that can be employed to customize fiber end properties. Our approach combines materials science, chemistry, and plant sciences to illustrate the innovation required to find alternative solutions for sustainable production of functional cotton fibers with enhanced and emergent properties.
| Item Type: | Article |
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| Additional Information: | Acknowledgements: We want to thank Dr. Samuel Bod\u00E9 and Dr. Katja Van Nieuland (Isotope Bioscience Laboratory (ISOFYS), Faculty of Bioscience Engineering, Belgium) for their help with EA-IRMS measurements. We want to thank Luis Favas for the illustrations. This work was funded by the European Union, ERC Consolidator project BIOMATFAB (project #101045466); a GIF German-Israeli Foundation for Scientific Research and Development research grant #I-1509-302.5/2019; the MINERVA Stiftung (project # 136809), with the funds from the BMBF of the Federal Republic of Germany, Benoziyo Endowment Fund for the Advancement of Science; a research grant from the Yotam project, the Weizmann Institute Sustainability and Energy Research Initiative (SAERI); the Moskowitz Center at the Weizmann Institute of Science for Nano and Bio-Imaging funding; and the University of Manchester. Views and opinions expressed are, however, those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council. Neither the European Union nor the granting authority can be held responsible for them. ToF-SIMS analysis was carried out with support provided by the National Science Foundation CBET-1626418. This work was conducted in part using resources of the Shared Equipment Authority at Rice University (USA). Data were generated in part by accessing research infrastructure at University of Copenhagen, including FOODHAY (Food and Health Open Innovation Laboratory, Danish Roadmap for Research Infrastructure). O.A.K. performed growth cotton ovules in vitro experiments, performed single-fiber mechanical testing, and wrote and revised the manuscript. P.A. performed the chemosynthesis of 6F-Glc-1P and wrote and revised the manuscript. X.S. performed the wettability experiments, analyzed and interpreted the data, and wrote and revised the manuscript. R.M. performed the cross-sections and the elemental analysis of the fibers' cross-sections, analyzed and interpreted the data, and wrote and revised the manuscript. I.K.-A. performed the wettability experiments, analyzed and interpreted the data, and wrote and revised the manuscript. Q.J. performed the water sorption dynamics measurements, analyzed and interpreted the data, and wrote and revised the manuscript. T.T. performed the ToF-SIMS analysis of the 6F-Glc-1P and control fibers, analyzed and interpreted the data, and wrote and revised the manuscript. J.J.K.K. performed WAXS analysis 6F-Glc-1P and control fibers, analyzed and interpreted the data, and wrote and revised the manuscript. R.F. performed conceptualization, supervision, management, and funding acquisition and wrote and revised the manuscript. F.N. performed conceptualization, supervision, management, and funding acquisition and wrote and revised the manuscript. The authors declare no competing interests. |
| Uncontrolled Keywords: | cotton fibers,metabolic incorporation,modified properties,synthetic glucose derivatives,chemistry(all),materials science(all),engineering(all),energy(all),physics and astronomy(all) ,/dk/atira/pure/subjectarea/asjc/1600 |
| Faculty \ School: | Faculty of Science > School of Chemistry, Pharmacy and Pharmacology |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 03 Sep 2024 15:34 |
| Last Modified: | 25 Sep 2024 18:04 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96476 |
| DOI: | 10.1016/j.xcrp.2024.101963 |
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