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Baker, Alexander N., Hawker-Bond, George W., Georgiou, Panagiotis G., Dedola, Simone, Field, Robert A. 
ORCID: https://orcid.org/0000-0001-8574-0275 and Gibson, Matthew I.
(2022)
Glycosylated gold nanoparticles in point of care diagnostics: From aggregation to lateral flow.
Chemical Society Reviews, 51 (16).
pp. 7238-7259.
ISSN 0306-0012
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Abstract
Current point-of-care lateral flow immunoassays, such as the home pregnancy test, rely on proteins as detection units (e.g. antibodies) to sense for analytes. Glycans play a fundamental role in biological signalling and recognition events such as pathogen adhesion and hence they are promising future alternatives to antibody-based biosensing and diagnostics. Here we introduce the potential of glycans coupled to gold nanoparticles as recognition agents for lateral flow diagnostics. We first introduce the concept of lateral flow, including a case study of lateral flow use in the field compared to other diagnostic tools. We then introduce glycosylated materials, the affinity gains achieved by the cluster glycoside effect and the current use of these in aggregation based assays. Finally, the potential role of glycans in lateral flow are explained, and examples of their successful use given.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: This project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement n° 866056) and under the Marie Skłodowska-Curie grant agreement No. 814236. MIG is supported by a Royal Society (Industry Fellowship 191037). This research was funded in whole or in part by the BBSRC [BB/M01116X/1]. For the purpose of open access, the author has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising from this submission. This work was also supported by Iceni Glycoscience. Electron micrograph reproduced from van den Berg et al.127 (figure 75.1.) under licence from Cambridge University Press, PLSclear Ref No: 53530 Publisher Copyright: © 2022 The Royal Society of Chemistry. |
| Uncontrolled Keywords: | chemistry(all) ,/dk/atira/pure/subjectarea/asjc/1600 |
| Faculty \ School: | Faculty of Science > School of Chemistry, Pharmacy and Pharmacology |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 03 Sep 2024 13:32 |
| Last Modified: | 12 Sep 2024 15:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96470 |
| DOI: | 10.1039/d2cs00267a |
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