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Ahmadipour, Sanaz, Field, Robert A. 
ORCID: https://orcid.org/0000-0001-8574-0275 and Miller, Gavin J.
(2021)
Prospects for anti-Candida therapy through targeting the cell wall: A mini-review.
The Cell Surface, 7.
ISSN 2468-2330
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Abstract
The impact of fungal infections on humans is a serious public health issue that has received much less attention than bacterial infection and treatment, despite ever-increasing incidence exacerbated by an increased incidence of immunocompromised individuals in the population. Candida species, in particular, cause some of the most prevalent hospital-related fungal infections. Fungal infections are also detrimental to the well-being of grazing livestock, with milk production in dairy cows, and body and coat condition adversely affected by fungal infections. Fungal cell walls are essential for viability, morphogenesis and pathogenesis: numerous anti-fungal drugs rely on targeting either the cell wall or cell membrane, but the pipeline of available bioactives is limited. There is a clear and unmet need to identify novel targets and develop new classes of anti-fungal agents. This mini review focuses on fungal cell wall structure, composition and biosynthesis in Candida spp., including C. auris. In addition, an overview of current advances in the development of cell wall targeted therapies is considered.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: Innovative UK for an Innovation Scholar Secondment to SA (UKRI, 76242: Sugars, Enzymes and Diagnostics (SEAD)). GM is supported by a UKRI Future Leader Fellowship (MR/T019522/1). |
| Uncontrolled Keywords: | chitin,fungal cell wall,glycoproteins,inhibitors,vaccines,microbiology,applied microbiology and biotechnology,molecular biology,cell biology,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2400/2404 |
| Faculty \ School: | Faculty of Science > School of Chemistry, Pharmacy and Pharmacology |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 03 Sep 2024 09:37 |
| Last Modified: | 25 Sep 2024 18:05 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96467 |
| DOI: | 10.1016/j.tcsw.2021.100063 |
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