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Zhang, Hanyan, Sun, Dandan, Wang, Guanzhen, Cui, Shichao, Field, Robert A. 
ORCID: https://orcid.org/0000-0001-8574-0275, Li, Jia and Zang, Yi
(2019)
Alogliptin alleviates liver fibrosis via suppression of activated hepatic stellate cell.
Biochemical and Biophysical Research Communications, 511 (2).
pp. 387-393.
ISSN 0006-291X
Abstract
Liver fibrosis occurs in most types of chronic liver diseases. The understanding of the pathogenesis of liver fibrosis has grown considerably, but the effective treatments are still lacking. Alogliptin, a classical Dipeptidyl peptidase-4 (DPP4) inhibitor with great effects on type 2 diabetes, has shown the potential to protect liver, but its effects on the progression of liver fibrosis have not been clarified. Herein, we explored the anti-fibrosis effects of alogliptin. In vitro, we demonstrated that alogliptin suppressed the activation of LX-2 upon transforming growth factor-β (TGF-β) challenge. In vivo, chronic treatment with alogliptin alleviated hepatic steatosis and protected from the liver injury in ob/ob mice, which delayed the progression of liver fibrosis. Furthermore, alogliptin significantly relieved the hepatic fibrosis in CCl4-induced liver fibrosis mouse model. In conclusion, our results demonstrate that negatively modulation of alogliptin on hepatic stellate cell (HSC) activation might contribute to liver fibrosis alleviation. Our research provides the potential possibility of alogliptin on the application for liver fibrosis therapy and suggests that DPP4 may be a novel target for liver fibrosis therapy.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: This work is supported by the National Natural Science Foundation of China (Grant 31871414 , 81673489 ), Science and Technology Commission of Shanghai Municipality (Grant 16430724100 ), and K. C. Wong Education Foundation . Publisher Copyright: © 2019 Elsevier Inc. |
| Uncontrolled Keywords: | alogliptin,dpp4,hepatic stellate cell,liver fibrosis,biophysics,biochemistry,molecular biology,cell biology,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1304 |
| Faculty \ School: | Faculty of Science > School of Chemistry, Pharmacy and Pharmacology |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 02 Sep 2024 15:31 |
| Last Modified: | 25 Sep 2024 18:05 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96453 |
| DOI: | 10.1016/j.bbrc.2019.02.065 |
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