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He, Xiao Peng, Zhang, Chao, Wang, Guanzhen, Han, Hai Hao, Hu, Xi Le, Field, Rob 
ORCID: https://orcid.org/0000-0001-8574-0275, Chen, Guo Rong, Li, Jia, Ye, Bing and Zang, Yi
(2019)
Self-assembled thin-layer glycomaterials with an appropriate shell thickness for targeted and activatable cell imaging.
Frontiers in Chemistry, 7 (APR).
ISSN 2296-2646
Abstract
The construction of targeted and activatable materials can largely improve the precision of disease diagnosis and therapy. However, the currently developed systems either target a transmembrane antigen or are activatable to release imaging and/or therapeutic reagents intracellularly. Here we develop a simple thin-layer glycomaterial through the self-assembly between fluorescent glycoprobes, in which the carbohydrate targeting reagent and the fluorophore are linked to each other by polyethlene glycol with a suitable chain length, and thin-layer manganese dioxide. The fluorogenic material developed is both capable of targeting a transmembrane glycoprotein receptor 'and' fluorescently activatable by intracellular biothiols. The shell thickness of the material was determined to be important for achieving the biothiol-induced activation of fluorescence. This research might provide insight into the development of precision-enhanced self-assembled materials for disease theranostics.
| Item Type: | Article |
|---|---|
| Additional Information: | Publisher Copyright: © 2019 He, Zhang, Wang, Han, Hu, Field, Chen, Li, Ye and Zang. |
| Uncontrolled Keywords: | 2d material,fluorescence,hsa,imaging,receptor,chemistry(all) ,/dk/atira/pure/subjectarea/asjc/1600 |
| Faculty \ School: | Faculty of Science > School of Chemistry, Pharmacy and Pharmacology |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 02 Sep 2024 15:31 |
| Last Modified: | 25 Sep 2024 18:05 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96452 |
| DOI: | 10.3389/fchem.2019.00294 |
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