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Hu, Xi Le, Cai, Quanyu, Gao, Jie, Field, Robert A. 
ORCID: https://orcid.org/0000-0001-8574-0275, Chen, Guo Rong, Jia, Ningyang, Zang, Yi, Li, Jia and He, Xiao Peng
(2019)
Self-Assembled 2D Glycoclusters for the Targeted Delivery of Theranostic Agents to Triple-Negative Breast Cancer Cells.
ACS Applied Materials and Interfaces, 11 (25).
pp. 22181-22187.
ISSN 1944-8244
Abstract
Triple-negative breast cancer (TNBC) is a devastating disease worldwide, for which targeted imaging and therapeutic agents remain elusive. There has been growing awareness that carbohydrates are valuable as drug candidates and targeting agents for a variety of human diseases, including cancers that overexpress carbohydrate receptors on the cell surface. Here, we develop a two-dimensional (2D) glycocluster by means of simple, stepwise self-assembly for the targeted delivery of theranostic agents to TNBC cells that express mannose receptors (MRs) on the cell surface. Human serum albumin, which contains a variety of hydrophobic pockets capable of accommodating small molecules, was used to simultaneously encapsulate a mannose-based glycoprobe and a commercial photosensitizer (i.e., Ce6). The multicomponent "neoglycoprotein" formed was used to self-assemble with 2D MnO2, producing 2D glycoclusters, which could be selectively internalized by a TNBC cell line (MDA-MB-231) as facilitated by binding to the transmembrane MR. The intracellular degradation of the 2D MnO2 backbone by biothiols then released Ce6 for cell imaging and, subsequently, photodynamic therapy. This study provides insights into the development of carbohydrate-based materials for targeted, stimuli-responsive theranostics of TNBC.
| Item Type: | Article |
|---|---|
| Additional Information: | Publisher Copyright: © 2019 American Chemical Society. |
| Uncontrolled Keywords: | 2d material,breast cancer,glycocluster,self-assembly,theranostics,materials science(all),sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2500 |
| Faculty \ School: | Faculty of Science > School of Chemistry, Pharmacy and Pharmacology |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 02 Sep 2024 15:30 |
| Last Modified: | 25 Sep 2024 18:05 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96444 |
| DOI: | 10.1021/acsami.9b06016 |
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