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Dou, Wei Tao, Liu, Li Fang, Gao, Jie, Zang, Yi, Chen, Guo Rong, Field, Robert A. 
ORCID: https://orcid.org/0000-0001-8574-0275, James, Tony D., Li, Jia and He, Xiao Peng
(2019)
Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material.
Chemical Communications, 55 (88).
pp. 13235-13238.
ISSN 1359-7345
Abstract
Protein C receptor (PROCR) is a recently discovered transmembrane biomarker for several tissue stem cells and is highly expressed in triple-negative breast cancer (TNBC) patient-derived xenografts. Herein, to enrich the toolbox for the biochemical evaluation of PROCR, we have developed a peptide-functionalized fluorogenic 2D material based on the self-assembly between a fluorescent peptide probe and thin-layer molybdenum disulfide. The material developed was suitable for the sensitive detection of PROCR recombinant protein in buffer solution and the fluorescence imaging of TNBC cells that express high levels of PROCR.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: Prof. Yi Zeng is warmly thanked for her helpful discussion. This research was supported by the Natural Science Foundation of China (no. 21788102, 91853201, 21722801 and 21776078), the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03), the Shanghai Science and Technology Committee (No. 19410712600), and the National Postdoctoral Program for Innovative Talents (BX20190115). T. D. J. thanks the Royal Society for a Wolfson Research Merit Award. All cells were obtained from ATCC. Publisher Copyright: This journal is © The Royal Society of Chemistry. |
| Uncontrolled Keywords: | electronic, optical and magnetic materials,catalysis,ceramics and composites,chemistry(all),surfaces, coatings and films,metals and alloys,materials chemistry,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2500/2504 |
| Faculty \ School: | Faculty of Science > School of Chemistry, Pharmacy and Pharmacology |
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| Depositing User: | LivePure Connector |
| Date Deposited: | 02 Sep 2024 15:30 |
| Last Modified: | 25 Sep 2024 18:05 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96440 |
| DOI: | 10.1039/c9cc06399d |
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